Immunoglobulin heavy chain gene rearrangement

Heavy chain rearrangement is a stepwise process.

(1) Specific D and J segments are joined (D3-J5) and bridging DNA strand is excised.

(2) A second rearrangement occurs between V and DJ segments (see V3-D3J5).

(3) The rearranged DNA strand is transcribed into mRNA after splicing out of additional redundant V and J regions.

L: light chain gene segment; V_H: variable region of heavy chain; D: diversity; J_H: joining segment of heavy chain; Cµ: constant region of immunoglobulin M (IgM) heavy chain; mRNA: messenger ribonucleic acid; DNA: deoxyribonucleic acid.

Modified with permission from: Bona C, Bonilla FA. Textbook of Immunology, 2nd ed. Harwood Academic Publishers GmbH, Amsterdam 1996. Copyright © 1996 Overseas Publishers Association, NV. Permission granted by Gordon and Breach Publishers.

Graphic 72581 Version 6.0

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Immunoglobulin heavy chain gene rearrangement