Chromosomal nondisjunction during meiosis leads, after fertilization, to trisomy. Subsequent loss of one chromosome (rescue) could lead to the formation of cells with a chromosome from each parent or cells in which both chromosomes were from the disomic gamete.
Reprinted from Preece, MA, Moore, GE. Genomic Imprinting, Uniparental Disomy and Fetal Growth. Trends in Endocrinology and Metabolism 2000; 11:270. Copyright 2000, with permission from Elsevier Science.
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