Version May 2024
| Clinical features |
| Severe diarrhea (volume, frequency [>6 stools/day], abdominal pain) |
| Fever (≥102°F [38.9°C]) |
| Leukocytosis (≥15,000 white blood cells/microL) |
| Fecal leukocytes or occult blood |
| Hypoalbuminemia |
| Acute abdomen with no passage of stool due to ileus |
| Radiographic evidence of colitis: |
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| Pseudomembranous colitis (noted at endoscopy) |
| Risk factors and predisposing conditions |
| Antibiotic exposure in the past 10 weeks |
| Recent hospitalization |
| Acid suppressant exposure (proton pump inhibitors or histamine-2 receptor antagonists) |
| Gastrointestinal feeding tubes |
| Inflammatory bowel disease |
| Immunodeficiency (malignancy, solid organ or hematopoietic transplantation) |
| Cystic fibrosis |
| Hirschsprung enterocolitis |
| Structural or postoperative intestinal disorders |
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