Phenotypes and frequencies of leukemias in the presence of various breakpoint sites

FAB subtype	Percent all AML	Chromosome abnormality	Genes involved	Prognostic implication
MO - no maturation	±2	hypodiploidy	Not applicable	Not available
M1 - minimal maturation	±20	t(9;22)	BCR-ABL	Poor
M2 - limited maturation	±30	t(8;21)	ETO-AML1	Intermediate
With basophilia	<1	t(6;9)	DEK-CAN	Poor
M3 - promyelocytic	±10	t(15;17)	PML-RARA	Favorable, present in most patients
M4 - myelomonocytic	±25	t(...;11) or t(11;...)	MLL-other	Poor
M4E - myelomonocytic with eosinophilia	±10	t(16;16) or (inv)16	MYH11- CBFB	Favorable, present in most patients
M5 - monocytic	<2	t(9;11) t(...;11) or t(11;...)	AF9-MLL MLL-other	Favorable Poor
M6 - erythroleukemia	<2	t(3;5)	Not available	Poor
M7 - megakaryoblastic	<2	t(1;22)	Not available	Very poor

Cytogenetics_in_AML.htm

FAB: French American British Classification.

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