13-valent pneumococcal conjugate vaccine (PCV13) | 15-valent pneumococcal conjugate vaccine (PCV15) | 20-valent pneumococcal conjugate vaccine (PCV20) | Pneumococcal polysaccharide vaccine (PPSV23) | |
Trade name | Prevnar 13 | Vaxneuvance | Prevnar 20 | Pneumovax 23 |
Serotypes contained | 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 23F | 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F, 33F | 1, 3, 4, 5, 6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, 33F | 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, 33F |
Protein carrier | CRM197 (a nontoxic mutant of diphtheria toxin) | CRM197 (a nontoxic mutant of diphtheria toxin) | CRM197 (a nontoxic mutant of diphtheria toxin) | None |
Adjuvant | Aluminum phosphate | Aluminum phosphate | Aluminum phosphate | None |
Contains thimerosal? | No | No | No | No |
Dose | 0.5 mL | 0.5 mL | 0.5 mL | 0.5 mL |
Route | Intramuscular | Intramuscular | Intramuscular | Intramuscular or subcutaneous |
Target groups |
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Approved age groups | ≥6 weeks | ≥6 weeks | ≥6 weeks | ≥2 years |
Number of doses | Varies depending on age when series is initiated* | Varies depending on age when series is initiated | Varies depending on age when series is initiated | One or two depending upon risk group* |
Recommended schedule | 2, 4, 6, and 12 through 15 months | 2, 4, 6, and 12 through 15 months | 2, 4, 6, and 12 through 15 months | One dose of PPSV23 at age ≥2 years and ≥8 weeks after the last indicated dose of PCV13 A second dose (usually ≥5 years after the first) is recommended for children who are immunocompromised, including those who have sickle cell disease or functional or anatomic asplenia A second dose is not recommended for immunocompetent children with cochlear implants or chronic illness, including chronic heart disease, chronic lung disease, diabetes mellitus, and cerebrospinal fluid leaks |
May be administered with other vaccines? | Yes, except PPSV23 | Yes, except PPSV23 | Yes, except PPSV23 | Yes, except PCV13 or PCV15 |
IPD: invasive pneumococcal disease.
* Refer to UpToDate content on pneumococcal vaccination in children for details.آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟