Peripheral blood smear in hemoglobin SC disease

Peripheral blood smear from a patient with hemoglobin SC disease shows numerous target cells (red arrows), partially sickled "canoe" shaped erythrocytes (black arrows), and folded (Pita bread) red cells (blue arrows).

High-power view of a normal peripheral blood smear. Several platelets (arrowheads) and a normal lymphocyte (arrow) can also be seen. The red cells are of relatively uniform size and shape. The diameter of the normal red cell should approximate that of the nucleus of the small lymphocyte; central pallor (dashed arrow) should equal one-third of its diameter.