Version June 2024
| A. Five (or more) of the following symptoms have been present during the same 2-week period, and represent a change from previous functioning. At least one of the symptoms is either depressed mood or loss of interest or pleasure. |
| (Note: Do not include symptoms that are clearly due to a general medical condition, or mood-incongruent delusions or hallucinations.) |
| Depressed mood most of the day, nearly every day (or alternatively can be irritable mood in children and adolescents) |
| Markedly diminished interest or pleasure in all, or almost all, activities, nearly every day |
| Significant weight loss while not dieting, weight gain, or decrease or increase in appetite |
| Insomnia or hypersomnia nearly every day |
| Psychomotor agitation or retardation nearly every day |
| Fatigue or loss of energy nearly every day |
| Feelings of worthlessness or excessive or inappropriate guilt nearly every day |
| Diminished ability to think or concentrate, or indecisiveness, nearly every day |
| Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide |
| B. The symptoms do not meet criteria for a Mixed Episode. |
| C. The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning. |
| D. The symptoms are not due to the direct physiological effects of substance or a general medical condition. |
| E. The symptoms are not better accounted for by Bereavement, ie, after the loss of a loved one, the symptoms persist for longer than two months or are characterized by marked functional impairment, morbid preoccupation with worthlessness, suicidal ideation, psychotic symptoms, or psychomotor retardation. |
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