Effects of GnRH agonist alone (solid lines) versus GnRH agonist plus low-dose estrogen-progestin add-back (dotted line) on bone mineral density at the end of 6 months of treatment and then after 6 months of follow up
Effects of GnRH agonist alone (solid lines) versus GnRH agonist plus low-dose estrogen-progestin add-back (dotted line) on bone mineral density at the end of 6 months of treatment and then after 6 months of follow up
Note that the low-dose estrogen plus progestin add-back was associated with continuing bone loss during treatment, but the bone loss was less than that observed in the group treated with the GnRH agonist alone.