Regulation of thyroid hormone supply, metabolism, and genomic action

(A) Feedback control that regulates the circulating concentration of TH.
(B) Intracellular metabolism of TH, regulating TH bioactivity.
(C) Genomic action of TH. For details, refer to UpToDate text.

TRH: TSH-releasing hormone; TSH: thyroid-stimulating hormone (thyrotropin); T3: 3,3',5-triiodothyronine; T4: 3,5,3',5'-tetraiodothyronine (thyroxine); 5'D: deiodination by removal of an iodine from the 5' position of iodothyronine; 5D: 5-deiodination; T2: 3,3'-dioidothyronine; rT3: 3,3',5'-triiodothyronine (reverse T3); CBP/P300: cAMP-binding protein/general transcription adaptor; RXR: retinod X receptor; TR: thyroid hormone receptor; TFIIA and TFIIB: transcription intermediary factor II, A and B; TBP: TATA-binding protein; TAF: TBP-associated factor; TH: thyroid hormone.

From: Refetoff, S, Dumitrescu, A. Syndromes of reduced sensitivity to thyroid hormone: genetic defects in hormone receptors, cell transporters and deiodination. Best Pract Res Clin Endocrinol Metab 2007; 21(2):277. Copyright © 2007 Elsevier. Illustration used with permission of Elsevier, Inc. All rights reserved.

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Regulation of thyroid hormone supply, metabolism, and genomic action