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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Comparison of rotavirus vaccines licensed in the United States[1]

Comparison of rotavirus vaccines licensed in the United States[1]
  Pentavalent human-bovine reassortant vaccine (RV5, PRV)[2] Attenuated human rotavirus vaccine (RV1, HRV)[3,4]
Trade name RotaTeq Rotarix
Serotypes contained G1, G2, G3, G4, P1[8] G1P[8]
Presentation and dose Ready-to-use squeezable tube: 2 mL Ready to use:
  • Oral dosing applicator: 1.5 mL
  • Squeezable tube: 1.5 mL

Requires reconstitution:

  • Vial and oral dosing applicator: 1 mL
Number of doses 3 2
Recommended schedule 2, 4, 6 months 2, 4 months
Minimum age first dose 6 weeks 6 weeks
Maximum age first dose
United States 14 weeks, 6 days 14 weeks, 6 days
Europe 12 weeks 12 weeks
Minimal interval between doses 4 weeks 4 weeks
Maximum age last dose
United States 8 months, 0 days 8 months, 0 days*
Europe 24 weeks 24 weeks
Oral applicator Latex-free
  • Latex-free: Squeezable tube
  • Contains latex: Ready-to-use oral dosing applicator and oral dosing applicator with vial
Contains thimerosal No No

* The Advisory Committee on Immunization Practices recommends 8 months, 0 days as the maximum age for the last dose for both RV1 and RV5; this varies from the prescribing information for RV1, which indicates that the second dose be administered up to 24 weeks of age.[1,3,4]

¶ Contraindicated in children with a severe (anaphylactic) allergy to latex.
References:
  1. Cortese MM, Parashar UD, Centers for Disease Control and Prevention (CDC). Prevention of rotavirus gastroenteritis among infants and children: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2009; 58:1.
  2. RotaTeq. US Food and Drug Administration (FDA) approved product information. Revised April 2022. Available online at https://dailymed.nlm.nih.gov/dailymed/index.cfm (Accessed on January 03, 2023).
  3. Rotarix (oral dosing applicator). US Food and Drug Administration (FDA) approved product information. Revised November 2022. Available online at https://www.fda.gov/media/163009/download (Accessed on January 03, 2023).
  4. Rotarix (squeezable tube). US Food and Drug Administration (FDA) approved product information. Revised December 2022. Available online at https://www.fda.gov/media/163010/download (Accessed on January 03, 2023).
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