Hematologic parameters in sickle cell trait-alpha thalassemia

Number of functioning alpha globin genes	Hemoglobin (g/dL)	MCV (fL)	Hemoglobin S (percent)
4	13 to 15	80 to 90	35 to 45
3	13 to 14	75 to 85	30 to 35
2	12 to 13	70 to 75	25 to 30
1	7 to 10	50 to 55	17 to 25

This table shows the effect of the number of functioning alpha globin genes on hematologic parameters in patients with the combination of alpha thalassemia and sickle cell trait. (The absence of any functional alpha globin genes is incompatible with extrauterine life; the normal complement is four).

MCV: mean corpuscular volume.

Data from: Steinberg MH, Embury SH. Alpha-thalassemia in blacks: genetic and clinical aspects and interactions with the sickle hemoglobin gene. Blood 1986; 68:985.

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خرید پکیج

Hematologic parameters in sickle cell trait-alpha thalassemia