Agent | Class | Formulation | Composition | Test dose | Advantages | Disadvantages | Vessel size (mm) | Concentration (%) | Injection/vein (mL) | Max dose |
Polidocanol (Aethoxysclerol) | Detergent | 1% 3% | Hydroxypolyethoxydodecane, distilled, ethyl alcohol | 0.5 mL |
|
| <0.5 | 0.25 to 0.5 | 0.25 | 3% solution |
0.5 to 1 | 0.5 to 0.75 | 0.5 | 50 kg: 5 mL | |||||||
1 to 3 | 0.75 to 1 | 0.5 to 0.75 | 60 kg: 6 mL | |||||||
3 to 5 | 1 to 2 | 0.75 to 1 | 70 kg: 7 mL | |||||||
>5 | 3 to 5 | To max | 80 kg: 8 mL | |||||||
90 kg: 9 mL | ||||||||||
Hypertonic saline* | Osmotic | 14.6% 23.4% | Sodium chloride | Not required |
|
| <0.5 | 11.7 to 15 | 0.25 | None¶ |
0.5 to 1 | 11.7 to 15 | 0.5 | ||||||||
1 to 3 | 15 to 23.4 | 0.5 to 1 | ||||||||
3 to 5 | – | – | ||||||||
>5 | – | – | ||||||||
Sodium tetradecyl sulfate | Detergent | 1% 3% | Sodium 1-isobutyl-4thyloctyl sulfate, benzoyl alcohol 2%, phosphate | 0.5 mL |
|
| 0.2 to 1 | 0.1 to 0.3 | 0.25 | 10 mL of 3% solutionΔ |
1 to 3 | 0.25 to 0.5 | 0.5 | ||||||||
3 to 5 | 0.5 to 1 | 0.5 to 1 | ||||||||
>5 | 1.5 to 3 | To max | ||||||||
Glycerin | Osmotic | 72% | Glycerol, 1, 2, 3-propanetrial, glycerine | 0.5 mL |
|
| <1 | 25 to 72 | 0.25 | 10 mL of 72% solution |
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