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Components of the plasma fibrinolytic system

Components of the plasma fibrinolytic system
  Molecular weight (d) Activity
Plasminogen 88,000 (single chain) Proenzyme form of fibrinolytic enzyme
Plasmin 88,000 (two chain) Active fibrinolytic enzyme
TPA 70,000 (one/two chain) Enzyme present in tissues that coverts plasminogen to plasmin
UPA 54,000 (two chain)
Plasminogen activator (different from tPA)
α2PI 70,000 (single chain) Specific fast-acting inhibitor in plasma
PAI-1 40,000 (single chain) Fast-acting inhibitor of tPA (and UPA) secreted by endothelial cells)
d: Daltons; TPA: tissue plasminogen activator; UPA: urokinase-like plasminogen activator; α2PI: alpha-2 plasmin inhibitor; PAI-1: plasminogen activator inhibitor-1.
Graphic 70156 Version 3.0

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