Structure of romiplostim (Nplate, Romiplate, AMG 531)
Structure of romiplostim (Nplate, Romiplate, AMG 531)
Romiplostim is a "peptibody" composed of two disulphide-bonded human IgG1 kappa heavy chain constant regions (Fc fragment), each of which is covalently linked at residue 228 via polyglycine with two identical 14-amino acid TPO agonist peptide sequences.
Courtesy of Janet Nichol, Amgen, Inc, Thousand Oaks, CA.
Graphic 69951 Version 4.0
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