Version May 2024
| Entity | Histology | Immunophenotype | Genetic features/other |
| Lymphoplasmacytic lymphoma | ≥10 percent infiltration by small lymphocytes, plasmacytoid lymphocytes, and plasma cells, with variable numbers of admixed immunoblasts. Characteristic (but not pathognomonic) hyperplasia of mast cells in marrow. Lymph nodes are usually diffusely effaced. Proliferation centers and marginal zone type differentiation are absent. | Express pan B-cell antigens (CD19, CD20, CD22, CD79a). Most, but not all, cases fail to express CD5. Variable expression of CD11c, CD43, CD25. Most cases express IgM; fewer express IgG or IgA. CD10 and cyclin D1 are not expressed. | Majority have a monoclonal IgM paraprotein. No specific chromosomal abnormalities. |
| Chronic lymphocytic leukemia/small lymphocytic lymphoma | "Typical" CLL/SLL cells are small mature appearing lymphocytes with a dense nucleus, partially aggregated chromatin, no discernible nucleoli, and a narrow border of clear to slightly basophilic cytoplasm. | Always express CD5, usually CD23 positive. Dim expression of CD20 and surface Ig. | Del13q, del 11q, del17p, trisomy 12 |
| B-cell prolymphocytic leukemia | Prolymphocytes >55 percent of the neoplastic cells. Bone marrow has interstitial pattern of infiltration. Lymph nodes may show vague nodularity, but proliferation centers are absent. | Express bright surface IgM +/- IgD and bright CD20 as well as other B-cell antigens (CD19, CD22, CD79a, FMC7). | t(11;14) must be excluded. No associated paraproteinemia. |
| Follicular lymphoma | Nodular growth pattern of follicle center cells (centrocytes and centroblasts). | Typically express CD10, HLA-DR, pan B-cell antigens (CD19, CD20, CD79a), CD21, and surface IgM, IgG, or IgA. | t(14;18) |
| Multiple myeloma | Infiltration of plasma cells in the bone marrow. | Surface Ig is absent. Express CD138, CD38, CD79a, and VS38c. Infrequently express CD19. Approximately 70 percent of myeloma cells will express CD56. | Cytogenetics usually abnormal, although there is no specific cytogenetic abnormality. |
| Mantle cell lymphoma | Monomorphous small to medium-sized B lymphocytes with irregular nuclei. | CD5+ and CD23-; typically co-express surface IgM and IgD; the vast majority over-express cyclin D1. | t(11;14) |
| Marginal zone lymphoma | Polymorphous infiltrate of small cells with paler-appearing marginal zone-type differentiation in lymph nodes. | Expresses B cell markers CD19, CD20, and CD22, and not CD5, CD10, and CD23. | Chromosomal abnormalities, usually trisomy 3 or t(11;18), are found in most cases. May demonstrate mixed cryoglobulinemia +/- hepatitis C infection. |
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