Version May 2024
| Congestive |
| Cirrhosis |
| Heart failure |
| Thrombosis of portal, hepatic, or splenic veins |
| Malignancy |
| Lymphoma, usually indolent variants |
| Acute and chronic leukemias |
| Polycythemia vera |
| Multiple myeloma and its variants |
| Essential thrombocythemia |
| Primary myelofibrosis |
| Primary splenic tumors |
| Metastatic solid tumors |
| Infection |
| Viral – Hepatitis, infectious mononucleosis, cytomegalovirus |
| Bacterial – Salmonella, Brucella, tuberculosis |
| Parasitic – Malaria, schistosomiasis, toxoplasmosis, leishmaniasis |
| Infective endocarditis |
| Fungal |
| Inflammation |
| Sarcoid |
| Serum sickness |
| Systemic lupus erythematosus |
| Rheumatoid arthritis (Felty syndrome) |
| Infiltrative, nonmalignant |
| Gaucher disease |
| Niemann-Pick disease |
| Amyloid |
| Other lysosomal storage diseases (eg, mucopolysaccharidoses) |
| Langerhans cell histiocytosis |
| Hemophagocytic lymphohistiocytosis |
| Rosai-Dorfman disease |
| Hematologic (hypersplenic) states |
| Acute and chronic hemolytic anemias, all etiologies |
| Sickle cell disease (children) |
| Following use of recombinant human granulocyte colony-stimulating factor |
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