Small lymphocytes versus large granular lymphocytes

Distinction between small lymphocytes (A) and large granular lymphocytes (B) on blood smears. The large granular lymphocyte is about twice the size of the red cells and has abundant cytoplasm containing azurophilic granules. Micrographs were viewed with a Leica Leitz DMRB microscope using a 100x/1.30 oil immersion objective. Images were captured with a Sony Exwave HAD camera and manipulated using Tribyn Version 1.3 software.