Relative risks of major complications of chronic kidney disease based upon categorical meta-analysis

Summary of categorical meta-analysis (adjusted relative risk) for general population cohorts with ACR. Mortality is reported for general population cohorts assessing albuminuria as urine ACR. Kidney outcomes are reported for general population cohorts assessing albuminuria as either urine ACR or dipstick. eGFR and albuminuria are expressed as categorical variables. All results are adjusted for covariates and compared with the Ref. Each cell represents a pooled RR from a meta-analysis; bold numbers indicate statistical significance at p<0.05. Incidence rates per 1000 person-years for the reference cells are 7.0 for all-cause mortality, 4.5 for CVD mortality, 0.04 for kidney failure, 0.98 for AKI, and 2.02 for kidney disease progression. Absolute risk can be computed by multiplying the RRs in each cell by the incidence rate in the reference cell. Colors reflect the ranking of adjusted RR. The point estimates for each cell were ranked from 1 to 28 (the lowest RR having rank number 1, and the highest number 28). The categories with rank numbers 1 through 8 are green; rank numbers 9 through 14 are yellow; rank numbers 15 through 21 are orange; and trank numbers 22 through 28 are colored red. (For the outcome of kidney disease progression, two cells with RR of 1.0 are also green, leaving fewer cells as orange.)