Disorder | Type of malignancy |
Chromosomal disorders | |
Down syndrome | Leukemia, testicular, retinoblastoma |
Turner syndrome | Neurogenic, gonadal, endometrial |
Klinefelter syndrome | Leukemia, germ cell tumors |
Other sex aneuploidy | Retinoblastoma |
XY gonadal dysgenesis | Gonadoblastoma, dysgerminoma |
Trisomy 13 | Teratoma, leukemia, neurogenic |
Trisomy 18 | Neurogenic, Wilms tumor |
XYY, XYY mosaic | Osteosarcoma, medulloblastoma |
Other genetic disorders | |
Xeroderma pigmentosum | Basal, squamous cell carcinoma, melanoma |
Bloom syndrome | Leukemia, lymphoma, gastrointestinal |
Fanconi anemia | Leukemia, hepatoma, squamous cell carcinoma |
Ataxia-telangiectasia | Lymphoma, leukemia, Hodgkin disease, brain, gastric, ovarian, other epithelial |
Neurofibromatosis type 1 | Gliomas, malignant peripheral nerve sheath tumors |
Tuberous sclerosis | Brain tumors, rhabdomyosarcomas |
Von Hippel-Lindau disease | Renal cell carcinoma, pheochromocytoma |
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