Characteristics of B cell subsets

	B-1a	B-1b	B-2, "Conventional"
CD5	Constitutive	Inducible	Inducible
CD11b/CD18	Yes	Yes	No
CD45RA	Low	Low	High
Immunoglobulins	Low-affinity	High-affinity	High-affinity
	Polyreactive	Specific	Specific
	Germline VH, VL	Mutated VH, VL	Mutated VH, VL
	IgM	IgG, IgA, IgE	IgG, IgA, IgE
Origin	Self-replenishing	Bone marrow	Bone marrow
Location	Blood	Blood	Blood
Location	Peritoneal cavity	Follicular mantle	Follicular mantle
CD5 ligation	Induce TNF and IL-2R	Apoptosis	Apoptosis

B_cell_subsets.htm

VH: heavy chain variable region genes; VL: light chain variable region genes; TNF: tumor necrosis factor; IL-2R: interleukin-2 receptor. CD45A is the high molecular weight form of CD45 (leukocyte common antigen).

Data from Youinou, P, Jamin, C, Lydyard, PM. Immunol Today 1999; 20:312. (page 314, table2).

Graphic 68762 Version 1.0

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Characteristics of B cell subsets