ZAP-70 protein diagram, showing N- and C-SH2 domains, interdomains, I-A and I-B, and kinase domain. Mutation sites in the family are bolded; previously reported mutations in combined immunodeficiency patients (all of which are loss of function) are italicized.
ZAP-70: zeta chain-associated protein kinase 70; SH2: Src homology 2.