Diseases associated with symptomatic IgM deficiency

Respiratory

Bronchitis, pneumonia, rhinosinusitis, otitis media

Increased atopy: Allergic rhinitis, asthma

Pulmonary interstitial disease?*

Infectious disease

Sepsis (meningococcal, others)

Meningococcal nasopharyngitis

Generalized vaccinia

Epidermodysplasia verruciformis

Occupational small pox

Recurrent staphylococcal pyoderma

Disseminated molluscum contagiosum

Brucellosis

Autoimmune disease

Systemic lupus erythematosus

Hashimoto's thyroiditis

Chronic idiopathic thrombocytopenic purpura

Neoplastic disease

Clear cell sarcoma

Prolymphocytic leukemia

Gastrointestinal disease

Crohn disease

Others

Bloom syndrome

Inability to train (athlete)

Splenomegaly

IgM: immunoglobulin M.
* Possible association.

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