Combinations of hormonal therapy plus NSAIDs in the treatment of desmoid tumors

Agents used	Number of patients	Duration of therapy (in months)	Response	Duration of response	Author; year
Sulindac plus tamoxifen	25*	5 to 84 (median 24)	3 CR 3 PR 11 SD 7 PD	NR	Hansmann A; 2003
Hormonal agent (testolactone/tamoxifen) combined with an NSAID (indomethacin, sulindac, or piroxicam)	7	1 to 92 (median 52)	1 CR 4 PR 1 SD 1 PD	NR	Waddell W; 1991
Sulindac or indomethacin plus tamoxifen	4	9 to 36 (median 20)	2 SD 2 PD	NR	Klein W; 1987

NSAIDs: nonsteroidal antiinflammatory drugs; CR: complete response; PR: partial response; SD: stable disease; PD: progressive disease; NR: not reported.
* 1 out of 25 patients had a complete (R0) resection and was on combination therapy adjuvantly. This patient is not counted for responses.

Graphic 68431 Version 4.0

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Combinations of hormonal therapy plus NSAIDs in the treatment of desmoid tumors