Version June 2024
| S-100 | MART-1/Melan-A | HMB-45 | MITF-1 | Tyrosinase | SOX10 | PRAME | |
| Antigen makeup | Calcium-binding protein | Melanocyte differentiation antigen expressed as a transmembrane protein | Part of gp 100 complex (premelanosome complex) | Transcription regulator of tyrosinase gene | Key enzyme in melanin biosynthesis | Transcription factor: SRY-related HMG-box 10 (SOX10) protein | Membrane-bound protein involved in autologous cytotoxic T cell response |
| Staining targets | Melanoma, benign nevic cells (activated junctional nevi, dermal nevic cells in patients with HIV, blue nevi, and deep penetrating nevi), schwannomas, neurofibromas, and malignant peripheral nerve sheath tumors, among others | Cells of melanocytic lineage, modified perivascular smooth muscle cells of lymphangiomyomatosis, clear cell sugar tumor of the lung, renal angiomyolipoma, adrenocortical tumors, and tumors of the ovary | Most melanomas, fetal and neonatal melanocytes, intraepidermal and superficial dermal components of benign nevi, blue nevi, and deep penetrating nevi | Melanoma, benign melanocytes, some perivascular epithelioid cell carcinoma, and clear cell carcinoma | Melanoma, normal melanocytes, and nevi | Neural crest cells, including melanocytes, breast myoepithelial cells | Melanoma, head and neck cancer, breast cancer, renal cell carcinoma, non-small-cell lung cancer, hematologic malignancies |
| Staining location | Nucleus | Cytoplasm | Cytoplasm | Nucleus | Cytoplasm | Nucleus | Nucleus |
| Comments | Very high sensitivity but low specificity | Sensitive and specific for melanocytes but is not a marker of malignant transformation | Does not react with spindle cell melanomas | A promising marker that may be more sensitive and specific than other commercially available markers | May have higher sensitivity for metastatic tumors than HMB-45 or MART-1 | Nuclear staining pattern offers easier distinction from cytoplasmic melanin | Diffuse staining in over 90% of nondesmoplastic melanomas |
آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
