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Prognostic factors for CTLS in AML in the training sample: multivariate analysis and risk scores

Prognostic factors for CTLS in AML in the training sample: multivariate analysis and risk scores
Co-variate Unfavorable categories Regression coefficient

CTLS

Odds ratio (95% CI)

p value Score
WBC ≤25 x 109/L 1.1 1 <0.001 0
25-75 x 109/L 2.7 (1.4-5.4) 1
>75 x 109/L 7.3 (2.0-29.1) 2
Uric acid ≤7.5 mg/dL 2.2 1 <0.001 0
>7.5 mg/dL 9.1 (3.3-26.6) 1
LDH ≤1 x ULN 1.2 1 0.005 0
1-4 x ULN 3.9 (1.5-10.8) 1
>4 x ULN 15.2 (2.2-96.8) 2
Prog_fac_CTLS_AML.htm
LTLS: laboratory tumor lysis syndrome; CTLS: clinical tumor lysis syndrome; WBC: white blood cell count; ULN: upper limit of normal.
Reproduced with permission from: Montesinos P, Lorenzo I, Martin G, et al. Tumor lysis syndrome in patients with acute myeloid leukemia: identification of risk factors and development of a predictive model. Haematologica 2008; 93:9. Copyright ©2008 Ferrata-Storti Foundation.
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