Version May 2024
| Organ | Stage | Description |
| Skin | 1 | Maculopapular rash over <25% of body area |
| 2 | Maculopapular rash over 25 to 50% of body area | |
| 3 | Generalized erythroderma | |
| 4 | Generalized erythroderma with bullous formation and often with desquamation | |
| Liver | 1 | Bilirubin 2.0 to 3.0 mg/dL |
| 2 | Bilirubin 3.1 to 6.0 mg/dL | |
| 3 | Bilirubin 6.1 to 15.0 mg/dL | |
| 4 | Bilirubin >15.0 mg/dL | |
| Gut | 1 | Diarrhea >30 mL/kg or >500 mL/day |
| 2 | Diarrhea >60 mL/kg or >1000 mL/day | |
| 3 | Diarrhea >90 mL/kg or >1500 mL/day | |
| 4 | Diarrhea >90 mL/kg or >2000 mL/day; or severe abdominal pain with or without ileus | |
| Glucksberg grade | ||
| I – Stage 1 or 2 skin involvement; no liver or gut involvement; ECOG PS 0 | ||
| II – Stage 1 to 3 skin involvement; Grade 1 liver or gut involvement; ECOG PS 1 | ||
| III – Stage 2 or 3 skin, liver, or gut involvement; ECOG PS 2 | ||
| IV – Stage 1 to 4 skin involvement; Stage 2 to 4 liver or gut involvement; ECOG PS 3 | ||
| International Bone Marrow Transplant Registry Severity Index | ||
| A – Stage 1 skin involvement; no liver or gut involvement | ||
| B – Stage 2 skin involvement; Stage 1 to 2 gut or liver involvement | ||
| C – Stage 3 skin, liver, or gut involvement | ||
| D – Stage 4 skin, liver, or gut involvement | ||
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