Phenotypes of mice lacking specific hematopoietic growth factors or growth factor receptors

	Phenotype
Missing hematopoietic growth factor or growth factor receptor
GM-CSF	Normal hematopoiesis and progenitors
	Progressive accumulation of pulmonary surfactant
G-CSF	Circulating neutrophils 25 percent of normal
	Progenitors 50 percent of normal
	Impaired response to Listeria monocytogenes infection
IL-3/GM-CSF/IL-5 (bc) receptor	Similar to mice lacking GM-CSF
	Low eosinophils and impaired eosinophil response to N. brasiliensis
Missing transcription factor
PU.1	Embryonically lethal
	Absence of granulocytes, monocytes, T and B lymphocytes
C/EBP-alpha	Death soon after birth
	Absent neutrophils and eosinophils
	Impaired glucose metabolism
C/EBP-beta	Defective monocytes
	Myelodysplasia
C/EBP-epsilon	Early death from opportunistic infection and myelodysplasia
	Specific granule deficiency and abnormal neutrophil function
AML1 or CBF-beta	Embryonically lethal due to failure of hematopoiesis

For references, please refer to the UpToDate topic on the regulation of myelopoiesis.

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