Version June 2024
| Drug | Adult dosing | Pediatric dosing | Pregnancy* | |
| P. vivax P. ovale (chloroquine-sensitive) | Chloroquine OR Hydroxy-chloroquine¶ PLUS PrimaquineΔ | Chloroquine 600 mg base (=1000 mg salt) orally immediately, followed by 300 mg base (=500 mg salt) orally at 6, 24, and 48 hours. Total dose: 1500 mg base (=2500 mg salt) Hydroxychloroquine 620 mg base (=800 mg salt) orally immediately, followed by 310 mg base (=400 mg salt) orally at 6, 24, and 48 hours. Total dose: 1550 mg base (=2000 mg salt) PrimaquineΔ◊ 30 mg base orally once daily for 14 days | Chloroquine 10 mg base/kg orally immediately, followed by 5 mg base/kg orally at 6, 24, and 48 hours. Total dose: 25 mg base/kg Hydroxychloroquine 10 mg base/kg orally immediately, followed by 5 mg base/kg orally at 6, 24, and 48 hours. Total dose: 25 mg base/kg PrimaquineΔ◊ 30 mg base orally once daily for 14 days | Chloroquine OR Hydroxy-chloroquine¶ |
| Chloroquine-resistant P. vivax§ (Papua New Guinea and Indonesia) | A. Mefloquine OR Atovaquone-proguanil (Malarone) PLUS PrimaquineΔ | A. Mefloquine 648 mg base (=750 mg salt) orally as initial dose, followed by 456 mg base (=500 mg salt) orally given 6 to 12 hours after initial dose (total dose = 1250 mg salt) Atovaquone-proguanil (Malarone) Adult tab = 250 mg atovaquone / 100 mg proguanil. 4 adult tabs orally once daily for 3 days Primaquine (as above) | A. Mefloquine 13.7 mg base/kg (=15 mg salt/kg) orally as initial dose, followed by 9.1 mg base/kg (=10 mg salt//kg) orally given 6 to 12 hours after initial dose (total dose = 25 mg salt/kg) Atovaquone-proguanil (Malarone) Peds tab=62.5 mg atovaquone/ 25 mg proguanil. All doses administered orally once daily for 3 days: 5 to 8 kg: 2 peds tabs; 9 to 10 kg: 3 peds tabs; 11 to 20 kg: 1 adult tab; 21 to 30 kg: 2 adult tabs; 31 to 40 kg: 3 adult tabs; >40kg: 4 adult tabs Primaquine (as above) | A. Mefloquine (only) |
| B. Quinine PLUS one of the following: Doxycycline Tetracycline PLUS PrimaquineΔ | B. Quinine¥ 542 mg base (=650 mg salt) orally three times daily x 3 to 7 days Doxycycline 100 mg orally twice daily x 7 days Tetracycline 250 mg orally four times daily x 7 days Primaquine (as above) | B. Quinine¥ 8.3 mg base/kg (=10 mg salt/kg) orally three times daily x 3 to 7 days Doxycycline‡ 2.2 mg/kg orally twice daily x 7 days Tetracycline‡ 25 mg/kg/day orally divided four times daily x 7 days Primaquine (as above) | B. Quinine (only) | |
| P. malariae P. knowlesii | Chloroquine OR Hydroxy-chloroquine¶ | Chloroquine (as above) Hydroxychloroquine (as above) | Chloroquine (as above) Hydroxychloroquine (as above) | Chloroquine OR Hydroxy-chloroquine¶ |
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