ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
medimedia.ir

Cancer and Leukemia Group B (CALGB) study 9111 chemotherapy regimen for acute lymphoblastic leukemia in adults

Cancer and Leukemia Group B (CALGB) study 9111 chemotherapy regimen for acute lymphoblastic leukemia in adults
Course I: Induction (4 weeks)
For patients <60 years old:
Cyclophosphamide IV 1200 mg/m2 Day 1
Daunorubicin IV 45 mg/m2/day Days 1-3
Vincristine IV 2 mg Days 1, 8, 15, 22
Prednisone PO 60 mg/m2/day Days 1-21
Asparaginase (E. coli) SC/IM 6000 units/m2 Days 5, 8, 11, 15, 18, 22
For patients ≥60 years old:
Cyclophosphamide IV 800 mg/m2 Day 1
Daunorubicin IV 30 mg/m2/day Days 1-3
Vincristine IV 2 mg Days 1, 8, 15, 22
Prednisone PO 60 mg/m2/day Days 1-7
Asparaginase (E. coli) SC/IM 6000 units/m2 Days 5, 8, 11, 15, 18, 22
All patients receive filgrastim (G-CSF) 5 mcg/kg subcutaneously once per day starting on day 4 and continuing until the ANC is >1000/microL on two consecutive determinations >24 hours apart.
Course IIA: Early intensification (4 weeks; repeat once for Course IIB)
Intrathecal methotrexate IT 15 mg Day 1
Cyclophosphamide IV 1000 mg/m2 Day 1
Mercaptopurine PO 60 mg/m2/day Days 1-14
Cytarabine SC 75 mg/m2/day Days 1-4, 8-11
Vincristine IV 2 mg Days 15, 22
Asparaginase (E. coli) SC/IM 6000 units/m2 Days 15, 18, 22, 25
Course III: CNS prophylaxis and interim maintenance (12 weeks)
Cranial irradiation   2400 cGy Days 1-12
Intrathecal methotrexate IT 15 mg Days 1, 8, 15, 22, 29
Mercaptopurine PO 60 mg/m2/day Days 1-70
Methotrexate PO 20 mg/m2 Days 36, 43, 50, 57, 64
Course IV: Late intensification (8 weeks)
Doxorubicin IV 30 mg/m2 Days 1, 8, 15
Vincristine IV 2 mg Days 1, 8, 15
Dexamethasone PO 10 mg/m2/day Days 1-14
Cyclophosphamide IV 1000 mg/m2 Day 29
Thioguanine PO 60 mg/m2/day Days 29-42
Cytarabine SC 75 mg/m2/day Days 29-32, 36-39
Course V: Prolonged maintenance (until 24 months from diagnosis)
Vincristine IV 2 mg Day 1 of every 4 weeks
Prednisone PO 60 mg/m2/day Days 1-5 of every 4 weeks
Mercaptopurine PO 60 mg/m2/day Days 1-28
Methotrexate PO 20 mg/m2 Days 1, 8, 15, 22
ANC: absolute neutrophil count; IT: intrathecal; IV: intravenous; IM: intramuscular; PO: oral; SC: subcutaneous.
Data from: Acute Leukemias VI: Prognostic factors and treatment strategies, Buchner T, Hiddeman W, Wormann B (Eds), Springer-Verlag, Berlin 1997. p.677; Larson RA, Dodge RK, Burns CP, Blood 1995; 85:2025; and Larson RA, Dodge RK, Linker CA, et al. Blood 1998; 92:1556-1564.
Graphic 67471 Version 10.0

آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟