Version May 2024
| Disorder | Gene | Clinical features |
| HSAN1 | SPTLC1 SPTLC2 ATL1 DNMT1 ATL3 | Most are autosomal dominant |
| Onset often in early adulthood but variable | ||
| Distal sensory loss, foot ulcers | ||
| Preservation of facial sensation | ||
| Variable muscle wasting and weakness | ||
| Variable neural deafness and dementia | ||
| HSAN2 | WNK1/HSN2 FAM134B KIF1A SCN9A | Autosomal recessive |
| Loss of pain, temperature, and tactile sensation | ||
| Recurrent infection and fractures of the digits | ||
| HSAN3 (familial dysautonomia) | IKBKAP | Autosomal recessive |
| Progressive sensorimotor neuropathy | ||
| Sympathetic autonomic dysfunction | ||
| Smooth tongue without fungiform papillae | ||
| HSAN4 (congenital insensitivity to pain with anhidrosis) | NTRK1 | Autosomal recessive |
| Profound loss of pain sensitivity | ||
| Defects in thermoregulation | ||
| Anhydrosis | ||
| Mild to moderate mental retardation | ||
| Microcephaly | ||
| Fungiform papillae are present | ||
| HSAN5 | NGFB | Autosomal recessive |
| Loss of pain and temperature sensation | ||
| Normal muscle strength | ||
| Normal reflexes | ||
| Normal nerve conduction | ||
| HSAN6 | DST | Autosomal recessive; Ashkenazi Jewish |
| Autonomic dysfunction | ||
| Absent fungiform papillae | ||
| Death by age 2 years | ||
| HSAN7 | SCN11A | Autosomal dominant |
| Congenital insensitivity to pain | ||
| Self-mutilation, slow wound healing, painless bone fractures | ||
| Gastrointestinal dysfunction | ||
| Hyperhidrosis | ||
| HSAN8 | PRDM12 | Autosomal recessive |
| Self-mutilation, insensitivity to pain | ||
| Soft tissue injuries | ||
| Corneal scarring | ||
| Hypohidrosis | ||
| HSAN and dementia | PRNP | Autosomal dominant |
| Dementia | ||
| Autonomic dysfunction | ||
| Sensory loss | ||
| Hereditary sensory neuropathy with spastic paraplegia | CCT5 | Autosomal recessive |
| Spastic paraplegia | ||
| Ulcerations of hands and feet | ||
| Insensitivity to pain | SCN9A | Autosomal recessive: Insensitivity to pain |
| Paroxysmal extreme pain disorder | ||
| Primary erythermalgia | Autosomal dominant: Paroxysmal extreme pain disorder Primary erythermalgia Small fiber neuropathy | |
| Small fiber neuropathy |
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