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NINDS-AIREN criteria for probable vascular dementia

NINDS-AIREN criteria for probable vascular dementia
The criteria for the clinical diagnosis of probable vascular dementia include all of the following:
Dementia
Defined by cognitive decline from a previously higher level of functioning and manifested by impairment of memory and of two or more cognitive domains (orientation, attention, language, visuospatial functions, executive functions, motor control, and praxis), preferably established by clinical examination and documented by neuropsychological testing; deficits should be severe enough to interfere with activities of daily living not due to physical effects of stroke alone.
Exclusion criteria: Cases with disturbance of consciousness, delirium, psychosis, severe aphasia, or major sensorimotor impairment precluding neuropsychological testing. Also excluded are systemic disorders or other brain diseases (such as AD) that in and of themselves could account for deficits in memory and cognition.
Cerebrovascular disease
Defined by the presence of focal signs on neurologic examination, such as hemiparesis, lower facial weakness, Babinski sign, sensory deficit, hemianopia, and dysarthria consistent with stroke (with or without history of stroke), and evidence of relevant CVD by brain imaging (CT or MRI) including multiple large vessel infarcts or a single strategically placed infarct (angular gyrus, thalamus, basal forebrain, or PCA or ACA territories), as well as multiple basal ganglia and white matter lacunes, or extensive periventricular white matter lesions, or combinations thereof.
A relationship between the above two disorders
Manifested or inferred by the presence of one or more of the following:
(a) Onset of dementia within three months following a recognized stroke;
(b) Abrupt deterioration in cognitive functions; or fluctuating, stepwise progression of cognitive deficits.
NINDS-AIREN: National Institute of Neurological Disorders and Stroke and the Association Internationale pour la Recherche et l’Enseignement Neurosciences; AD: Alzheimer disease; CVD: cerebrovascular disease; CT: computed tomography; MRI: magnetic resonance imaging; PCA: posterior cerebral artery; ACA: anterior cerebral artery.
Graphic 67333 Version 4.0

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