Expected results of tests for hemostatic function in representative bleeding disorders

Disorder	Platelet count	PT	aPTT	TT	Fibrinogen level
Vasculopathies, connective tissue diseases, or collagen disorders affecting skin	Normal	Normal	Normal	Normal	Normal or increased*
Thrombocytopenia	Decreased	Normal	Normal	Normal	Normal
Qualitative platelet abnormalities	Normal or decreased^¶	Normal	Normal	Normal	Normal
Hemophilia A or B (factor VIII or IX deficiency)	Normal	Normal	Prolonged	Normal	Normal
von Willebrand disease	Normal^Δ	Normal	Normal or prolonged^◊	Normal	Normal
Disseminated intravascular coagulation	Decreased	Prolonged	Prolonged	Prolonged	Decreased

Refer to UpToDate topics on the evaluation of unexplained bleeding or bruising for a discussion of these findings and our approach to the evaluation.

PT: prothrombin time; aPTT: activated partial thromboplastin time; TT: thrombin time.
* Fibrinogen may be elevated as an acute phase reactant in disorders of inflammation.
¶ The platelet count in myeloproliferative disorders is usually high (eg, essential thrombocythemia) and platelets may also be qualitatively abnormal, predisposing to hemorrhagic and thrombotic diatheses.
Δ The platelet count may be low in some patients with type 2B von Willebrand disease.
◊ The aPTT may be normal in those with factor VIII activity >40%.

Graphic 67121 Version 14.0

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Expected results of tests for hemostatic function in representative bleeding disorders