ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد ایتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
medimedia.ir

Postpartum hemorrhage: Management approaches requiring laparotomy

Postpartum hemorrhage: Management approaches requiring laparotomy
Author:
Michael A Belfort, MBBCH, MD, PhD, D.A. (SA), FRCSC, FRCOG, FACOG
Section Editors:
Charles J Lockwood, MD, MHCM
Dena Goffman, MD
Deputy Editor:
Vanessa A Barss, MD, FACOG
Literature review current through: Jul 2022. | This topic last updated: Aug 30, 2022.

INTRODUCTION — Postpartum hemorrhage (PPH) is an obstetric emergency with many potentially effective medical and surgical interventions for management (table 1). In patients with PPH who have had a vaginal birth or whose cesarean birth has been completed (closed abdomen), medical and minimally invasive approaches are the preferred treatment approaches; laparotomy is generally a last resort that is performed when less invasive interventions have failed. During cesarean birth, uterotonic medications and manual uterine massage and compression are still the initial treatments for bleeding due to atony, but operative interventions for control of hemorrhage are performed sooner since the abdomen is already open.

This topic will discuss treatment approaches for PPH that require laparotomy. Medical and minimally invasive management of patients with PPH is reviewed separately (see "Postpartum hemorrhage: Medical and minimally invasive management"). An overview of issues related to PPH (eg, incidence, pathogenesis, risk factors, clinical presentation and diagnosis, general principles of planning and management, morbidity and mortality, and recurrence) is also available separately. (See "Overview of postpartum hemorrhage".)

EVALUATION OF THE ABDOMEN — Following vaginal birth, midline laparotomy provides the best exposure of both the pelvis and abdomen for assessment and treatment of suspected pelvic bleeding, in the author's opinion. For patients undergoing or who are post-cesarean birth, the existing incision is used and extended laterally, if needed, to provide adequate exposure. A self-retaining retractor (eg, Balfour, Bookwalter, or Omni) helps to provide adequate lateral and superior exposure (superior exposure will be required if access to the aorta is needed).

The abdominal cavity is irrigated to remove blood and clots and inspected for the source of bleeding, which is usually from the uterus. The source of bleeding is often readily apparent (atony, retained placental fragments, uterine laceration, uterine incision) but may not be immediately recognized when it is inside the uterine cavity after vaginal birth or after closure of the uterine incision at cesarean, retroperitoneal (including vaginal and vulvar hematomas from trauma to branches of the pudendal or uterine arteries and veins), or due to a rupture of the posterior uterine wall. These sites should be systematically evaluated in patients with compensated shock (normal blood pressure with increasing heart rate).

Intra-abdominal blood without an obvious uterine rupture or bleeding vessel may be due to hepatic or splenic rupture, or rupture of a visceral artery aneurysm or pseudoaneurysm. (See "Overview of visceral artery aneurysm and pseudoaneurysm" and "Treatment of visceral artery aneurysm and pseudoaneurysm" and "Evaluation of splenomegaly and other splenic disorders in adults", section on 'Trauma/rupture'.)

TEMPORARY MEASURES FOR STABILIZING HEMODYNAMICALLY UNSTABLE PATIENTS — Severe bleeding often continues while the surgeon is preparing to perform and while performing surgical procedures for controlling hemorrhage. Temporizing maneuvers should be attempted prior to performing any surgical procedures, such as opening the retroperitoneum, that will take significant time before the source of bleeding is identified and/or controlled. Even a hysterectomy that seems like it will be easy to perform and uncomplicated can be very difficult in a patient with severe coagulopathy once the pelvis or retroperitoneum fills with blood and structures that were not bleeding start to bleed.

The following measures, in addition to fluid administration and transfusion of blood products, help to support the patient hemodynamically in preparation for and during surgical evaluation and treatment, and can be life-saving. The option chosen depends on the urgency to control bleeding, the source of bleeding (intrauterine versus extrauterine), and the surgeon's expertise and preference.

Patients at imminent risk of exsanguination

Manual aortic compression — If there is an imminent threat of exsanguination (ie, within a few minutes), the surgeon should apply direct pressure to the aorta to compress it against the vertebrae a few centimeters superior to the sacral promontory (figure 1); the bifurcation into the common iliac arteries is just distal to this point. Compression can be applied using a closed fist or the heel of the hand.

Alternatively, the aorta can be compressed just below the renal arteries, which will minimize collateral flow to the uterus from the ovarian and inferior mesenteric arteries. Compression at either site will slow the volume of bleeding and will afford a better opportunity for finding and controlling the source of hemorrhage. Compression just above the bifurcation may be easier to accomplish but is less effective than below the renal arteries because of the extensive collateral blood supply to the uterus.

Balloon occlusion of the aorta — For patients in danger of imminent exsanguination, an aortic catheter positioned below the renal arteries may temporize bleeding to allow for ongoing resuscitation and can be placed either using a percutaneous femoral approach or by introducing the balloon catheter directly into the aorta.

Percutaneous approach (REBOA) — Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a percutaneous aortic balloon placement technique used in trauma (military and civilian) and emergency department settings. In an appropriately equipped operating room, the balloon can be placed using ultrasound guidance or fluoroscopy. Minimal data on the use of this technique in obstetrics are available but suggest that in desperate situations, particularly in low-resource environments where surgical resources and blood banking are unavailable, REBOA by appropriately trained obstetricians may offer a minimally invasive approach to aid in resuscitation. It may also be used prophylactically before surgery in patients with placenta accreta spectrum [1]. Potential risks associated with the REBOA technique include distal organ ischemia [2]. (See "Placenta accreta spectrum: Management" and "Postpartum hemorrhage: Medical and minimally invasive management", section on 'Consider resuscitative endovascular balloon occlusion of the aorta'.)

Direct aortic approach — Intra-aortic balloon catheters have been used intraoperatively to stabilize patients in extreme emergencies where death from exsanguination is imminent, but evidence of safety and efficacy is limited to case reports [3,4].

A balloon catheter can be placed directly into the aorta at the bifurcation using a Seldinger technique (initial needle followed by a guidewire over which the balloon catheter is inserted). The catheter is advanced up the aorta, and the balloon is positioned below the renal arteries, above the inferior mesenteric arteries, and at or above the ovarian arteries (figure 1), and then inflated. This distance can be measured before insertion using the external markings on the catheter, and then the catheter is advanced to the selected marking. The position of the tip of the catheter can be palpated after inflation of the balloon.

This position should ensure substantial reduction in uterine blood flow. As discussed above for the manual compression, placing the intra-aortic balloon at a lower level that is just above the aortic bifurcation may not substantially reduce uterine blood flow because of the extensive collateral blood supply to the uterus. For example, the ovarian arteries supply the uterus via the utero-ovarian branches (figure 2); therefore, if the ovarian arteries are not occluded, then uterine blood flow may not be substantially reduced despite uterine artery, and even internal iliac artery, ligation. Similarly, the inferior mesenteric artery is continuous with the uterine arterial collateral system via the superior rectal artery and its posterior collaterals (lumbar and median sacral arteries); therefore, uterine blood flow may not be substantially reduced if the inferior mesenteric artery is not occluded. Even with balloon position above the inferior mesenteric artery, uterine blood flow can occur through collaterals from the superior mesenteric artery, whose origin is above the renal arteries, and via retrograde flow from the iliac arteries.

When the patient has been resuscitated, the balloon is deflated intermittently to prevent ischemic limb or colon complications from aortic occlusion, and distal pulses are monitored frequently. Consultation with a vascular surgeon is recommended, especially prior to removal of the catheter as repair of the insertion site is needed if the vascular catheter is larger than 7F.

Patients not at imminent risk of exsanguination

Uterine tourniquet — Tourniquets have been used to control bleeding at myomectomy, for other types of uterine hemorrhage, and may be useful as a temporizing measure in PPH [5-7]. A Penrose drain or urinary catheter is placed as low as possible around the lower uterine segment without incorporating the urinary bladder, and then the two ends are pulled in opposite directions and as tightly as possible around the corpus to mechanically occlude the vascular supply. A second or third tourniquet can also be applied as needed. The tourniquet(s) can be held in place with a clamp (figure 3). This procedure markedly reduces blood loss and allows time for the anesthesia team members to catch up with transfusion requirements. When the patient is hemodynamically stable, the tourniquet(s) is removed and the surgical procedure is completed. (See "Techniques to reduce blood loss during abdominal or laparoscopic myomectomy", section on 'Tourniquets'.)

Intrauterine balloon tamponade — Commercially available and improvised devices have been used successfully to tamponade bleeding from the uterine cavity after vaginal or cesarean birth. For each device, the intrauterine balloon is filled until bleeding is controlled; continued excessive bleeding indicates that tamponade is not effective. Intrauterine balloon tamponade has been used alone and in combination with uterine compression sutures ("uterine sandwich"). If a balloon catheter is in utero before placing a uterine compression stitch, it should be removed or deflated while the compression stitch is carefully placed. The compression suture does not prevent subsequent inflation of the balloon. The technique is described separately. (See "Postpartum hemorrhage: Use of intrauterine tamponade to control bleeding".)

Ligation of uterine and utero-ovarian arteries — Ligation of the uterine and utero-ovarian arteries (figure 2) can decrease uterine bleeding by reducing perfusion pressure in the myometrium. It will not completely control bleeding from uterine atony or placenta accreta spectrum but may decrease blood loss while other interventions are being attempted. It does not harm the uterus and does not appear to impact reproductive function [8]. (See 'Laceration of the uterine artery or utero-ovarian artery branches' below.)

Clamp across utero-ovarian ligaments — Placing a large clamp across the utero-ovarian ligaments bilaterally is a rapid and simple means of occluding uterine blood flow through ovarian artery collaterals; however, it also effectively ligates the fallopian tubes (figure 4), precluding future conception without in vitro fertilization. It will not completely control bleeding from uterine atony or placenta accreta spectrum but may decrease blood loss while other interventions are being attempted.

Pelvic packing — Pelvic packing to create tamponade pressure exceeding arterial pressure can control bleeding from small pelvic arteries. It can be useful as a temporizing measure in the management of broad ligament or retroperitoneal hematomas, lacerations that are difficult to repair because of their location or friable tissue, bleeding related to coagulopathy while coagulation factors are being replaced, and posthysterectomy bleeding. The technique is described below. (See 'Damage control approach for persistent bleeding after hysterectomy' below.)

Role of internal iliac (hypogastric) artery ligation — This technique is challenging even for an experienced pelvic surgeon, especially when there is a large uterus, limited exposure through a transverse lower abdominal incision, ongoing pelvic hemorrhage, or a patient with obesity. Successful and safe bilateral internal iliac artery ligation becomes even more difficult when attempted by a surgeon who rarely operates deep in the pelvic retroperitoneal space [9]. For these reasons, uterine compression sutures, uterine artery ligation, and arterial embolization have largely replaced this procedure.

Bilateral ligation of the internal iliac arteries reduces the pulse pressure of blood flowing to the uterus [10]. The utility of the procedure may be compromised when there are extensive collateral vessels (such as in placenta percreta). Reverse filling of the internal iliac arteries has been reported beyond the point of ligation via branches of the external iliac artery (inferior epigastric, obturator, deep circumflex iliac, and superior gluteal arteries) [11,12]. A technical description of the procedure is available separately. (See "Management of hemorrhage in gynecologic surgery", section on 'Internal iliac artery ligation'.)

In trauma surgery, vessel loops or tapes along with vascular clamps or Rummel tourniquets have been used for temporary reduction of internal iliac blood flow and then released subsequent to control of distal hemorrhage.

Role of intraoperative cell salvage — Arranging for cell salvage in patients at high risk for PPH appears to be economically reasonable, while routine use of cell salvage for all cesarean births probably is not [13-15]. Intraoperative cell salvage may be arranged before laparotomy or requested during laparotomy. The American College of Obstetricians and Gynecologists has acknowledged the safety and efficacy of intraoperative cell salvage in patients with PPH [16].

Institutions that offer reinfusion of salvaged blood should have designated personnel, which may include cross-trained operating room employee (eg, an anesthesia technician) or a member of a specialist service (eg, an extracorporeal technologist or perfusionist). These individuals are called to manage the cell salvage equipment and follow written policies and procedures for proper collection, labeling, and storage of the collected blood.

Autotransfusion of blood obtained by intraoperative cell salvage (with a leukocyte filter and washing) can reduce the use of allogeneic blood, but the reduction may be modest [13,17-22]. Although there is a theoretical concern that reinfusing amniotic fluid may cause amniotic fluid embolism, this has been documented only once [23], and may have been prevented with cell washing. Risk of maternal infection from infusion of bacterial contamination is also minimal. Salvaged blood may contain fetal erythrocytes [13], but this is not a major concern, as D alloimmunization in a D-negative mother can be prevented by administration of anti-D immune globulin. ABO incompatibility reactions cannot be prevented but are unlikely to be serious because the volume of fetal blood contamination is small and A and B antigens/antibodies are not fully developed at birth. These risks are probably less than or similar to those from allogeneic transfusion.

There are data in obstetric patients that cell salvage is a potential source of a substantial volume of blood for transfusion and reduces the need for allogenic transfusion. In a study of patients with obstetric hemorrhage in whom intraoperative blood salvage was performed and the blood was reinfused, the mean±standard deviation number of reinfused shed blood units was 1.2±1.1 units, and at least three patients received four, five, or eight reinfused shed blood units [24]. Another group estimated that the use of cell salvage for obstetric hemorrhage saved, on average, 0.68 units of allogeneic packed erythrocytes per patient (95% CI 0.49-0.88), translating to a 32 percent reduction in the use of allogeneic packed erythrocytes [14].

Technical issues of cell salvage are reviewed in detail separately. (See "Surgical blood conservation: Blood salvage".)

ETIOLOGY-BASED MANAGEMENT

General principles — A variety of surgical interventions are effective for controlling postpartum hemorrhage (PPH) [16]. Clinicians should use their clinical judgment in deciding whether to expend time attempting conservative interventions in a patient with severe hemorrhage who may be better served by hysterectomy, such as patients with placenta accreta spectrum or uterine rupture.

Cessation of severe hemorrhage depends on reversal of any coagulopathy, so every effort should be made to reverse contributing factors such as hypothermia, acidosis, and lack of clotting factors. Even if bleeding cannot be completely controlled initially, as long as more blood and blood products are infused than lost, hemodynamic stability can be achieved and maintained. (See "Postpartum hemorrhage: Medical and minimally invasive management", section on 'Transfuse red blood cells, platelets, plasma' and "Postpartum hemorrhage: Medical and minimally invasive management", section on 'Correct clotting factor deficiencies'.)

Myometrial lacerations — Serious hemorrhage from the uterine incision is generally caused by lateral extension of the incision. Bleeding from a hysterotomy incision can generally be controlled by suture ligation. The angles of a transverse incision should be clearly visualized to ensure that they, and any retracted vessels, are completely ligated. This generally requires exteriorization of the uterus with gentle traction and adequate visualization of the lateral areas of the uterus above and below the edges of the incision.

An enlarging hematoma (or swelling beneath the surface of the broad ligament) beyond the end of the incision or laceration suggests a retracted blood vessel with ongoing bleeding. Given the proximity of the ureter to the vaginal angle and bladder reflection, placement of hemostatic sutures laterally to control bleeding from an extension of a hysterotomy laceration or retracted vessel should be carried out with extreme caution. In this circumstance, the ureter should be identified prior to blind placement of additional sutures to "catch" the retracted vessel. This may require placement of ureteric stents to aid palpation of the ureters. In other cases, the ureter(s) may be easily seen and identified. Once the ureters can be seen or felt, the broad ligament may need to be opened to isolate the bleeder, or alternatively, sutures can be placed without opening the retroperitoneum while retracting the ureter safely aside. Once the hemorrhage has been controlled, the integrity of the ureter(s) should be ensured. (See 'Post-laparotomy inspection' below.)

Laceration of the uterine artery or utero-ovarian artery branches — Bilateral ligation of the uterine vessels (O'Leary stitch) is the preferred approach for controlling PPH from laceration of the uterine artery or branches of the utero-ovarian artery [25,26]. It is preferable to internal iliac artery ligation because the uterine arteries are more readily accessible, the procedure is technically easier, and there is less risk to major adjacent vessels and the ureters. (See 'Role of internal iliac (hypogastric) artery ligation' above.)

After identification of the ureter, a large curved needle with a #0 polyglycolic acid suture is passed through the lateral aspect of the lower uterine segment as close to the cervix as possible and then back through the broad ligament just lateral to the uterine vessels. If this does not control bleeding, the vessels of the utero-ovarian arcade are similarly ligated just distal to the cornua by passing a suture ligature through the myometrium just medial to the vessels, then back through the broad ligament just lateral to the vessels, and then tying to compress the vessels (figure 5).

Bilateral ligation of the arteries and veins (uterine and utero-ovarian) is often successful in controlling hemorrhage [26,27] but in some cases may not completely control it, and other methods (see below) may be needed. Bilateral ligation does not appear to affect future reproductive function [8]. Uterine necrosis and placental insufficiency in a subsequent pregnancy have not been described as complications [27,28]. However, there is a single case report of ovarian failure and development of intrauterine synechiae after postpartum ligation of the uterine, utero-ovarian, and ovarian arteries for PPH related to atony [29].

Atony — The nonsurgical interventions for reduction and control of bleeding due to atony are applied in rapid sequence until bleeding is controlled, which may be the result of the cumulative combined effect of multiple interventions. All patients with PPH related to atony receive uterine massage/manual compression and administration of uterotonic medications and tranexamic acid. (See "Postpartum hemorrhage: Medical and minimally invasive management".)

If these measures do not control bleeding, and the patient is hemodynamically stable, we rapidly move on to placement of uterine compression sutures, which are an effective method for reducing uterine blood loss related to atony.

If the patient is hemodynamically unstable, temporizing measures such as placement of a uterine tourniquet, insertion of an intrauterine balloon for tamponade, and/or ligation of the uterine and utero-ovarian arteries can reduce ongoing heavy blood loss before placing compression sutures, and may obviate the need for them. (See 'Patients not at imminent risk of exsanguination' above.)

Uterine compression sutures — The B-Lynch suture is the most common technique for uterine compression; several variations of this technique have been described and no technique has been proven significantly more effective than another [30]. Generally, longitudinal sutures are easier to place and safer than transverse sutures, but this may not always be the case.

Procedure-related complications, such as uterine necrosis, erosion, and pyometra, have been reported rarely [31-36]. Limited follow-up of patients who have had a uterine compression suture suggests that there are no adverse effects on fertility or future pregnancy outcome [8,37]. Although uterine synechiae have been reported on postpartum hysteroscopy or hysterosalpingogram, some of these patients may have also had curettage, which could account for the finding [38].

B-Lynch suture — The B-Lynch suture (named for Christopher Balogun-Lynch) envelops and compresses the uterus, similar to the result achieved with manual uterine compression [39]. In case reports and small series, it has been highly successful in controlling uterine bleeding from atony when other methods have failed [39-43]. The technique is relatively simple to learn, appears safe, preserves future reproductive potential, and does not increase the risk of placentation-related adverse outcomes in a subsequent pregnancy, but may increase chances of developing Asherman syndrome [44,45]. It should only be used in cases of uterine atony; it will not control hemorrhage from placenta accreta spectrum. It will not prevent PPH in future pregnancies [44].

A large Mayo needle with #1 or #2 chromic catgut (or any absorbable suture if catgut is unavailable) is used to enter and exit the uterine cavity laterally in the lower uterine segment (figure 6). A large suture is used to prevent breaking, and a rapid absorption is important to prevent a herniation of bowel through a suture loop after the uterus has involuted.

The suture is looped over the fundus and re-enters the lower uterine cavity through the posterior wall. The suture then crosses to the other side of the lower uterine segment, exits through the posterior wall, and is looped back over the fundus to enter the anterior lateral lower uterine segment opposite and parallel to the initial bites. The free ends are pulled tightly and tied down securely to compress the uterus, assisted by bimanual compression.

Proper patient positioning (eg, legs apart, patient flat, or, if stable, in slight reverse Trendelenburg) will enhance the ability to assess the efficacy of these efforts by allowing for better assessment of persistent vaginal bleeding.

The technique has been used alone and in combination with balloon tamponade. This combination has been called the "uterine sandwich." (See "Postpartum hemorrhage: Use of intrauterine tamponade to control bleeding".)

Other uterine compression suture techniques — Other techniques have been reported in small case series and represent modifications of the B-Lynch suture [41,46-53].

Hayman described placement of two to four vertical compression sutures from the anterior to posterior uterine wall without hysterotomy (figure 7); thus, this is a good choice for surgical treatment of atony after a vaginal birth [46,47,54]. A transverse cervicoisthmic suture can also be placed if needed to control bleeding from the lower uterine segment.

Pereira described a technique in which a series of transverse and longitudinal sutures of a delayed absorbable multifilament suture are placed around the uterus via a series of bites into the subserosal myometrium, without entering the uterine cavity (figure 8) [48]. Two or three rows of these sutures are placed in each direction to completely envelope and compress the uterus. The longitudinal sutures begin and end tied to the transverse suture nearest the cervix. When the transverse sutures are brought through the broad ligament, care should be taken to avoid damaging blood vessels, ureters, and fallopian tubes. The myometrium should be manually compressed prior to tying down the sutures to facilitate maximal compression.

Cho described a technique using multiple squares/rectangles (figure 9) [50,55].

Retroperitoneal bleeding — Identification of an isolated bleeding point in the retroperitoneum is often impossible. It is rarely advisable to open the retroperitoneum or attempt dissection of any nonexpanding hematoma or an expanding retroperitoneal hematoma in a coagulopathic, hemodynamically unstable patient. The temporizing procedures described above can be used to stabilize the patient before beginning retroperitoneal surgery. (See 'Temporary measures for stabilizing hemodynamically unstable patients' above.)

Topical hemostatic agents can be used to control mild diffuse bleeding from peritoneal surfaces (table 2).

If a discrete retroperitoneal vessel is responsible for hemorrhage, it is clamped and ligated with appropriate suture material. Bleeding adjacent to the uterus without clear bleeding points can be managed by ligation of uterine vessels.

If ineffective, ligation of the ipsilateral internal iliac artery usually stops the bleeding and avoids the delay associated with searching for the discrete source of bleeding. If bleeding does not respond to ipsilateral internal iliac artery ligation, then bilateral internal iliac artery ligation and/or pelvic packing may be necessary. If time allows, when retroperitoneal bleeding is present and efforts at controlling retroperitoneal bleeding are necessary, ureteral stents may allow palpation of the ureters and placement of hemostatic sutures with more confidence.

Given the technical difficulties of safely ligating the internal iliac arteries, especially in the setting of disseminated intravascular coagulation and ongoing bleeding, this should only be attempted by surgeons with experience in the procedure and only when adequate blood products and facilities are available.

For surgeons without the necessary experience, pressure over the bleeding point or area, resuscitation and reversal of any coagulopathy, and calling for help from an experienced surgeon are key temporizing measures. If the hospital has the capability for performing arterial embolization in the operating room, this may be an option. Removal of a hemodynamically unstable patient from an operating room to transport to an interventional radiology suite is not advised.

Management of retroperitoneal bleeding is discussed in more detail separately. (See "Management of hematomas incurred as a result of obstetric delivery", section on 'Retroperitoneal hematomas'.)

Placental abnormalities

Placenta accreta spectrum — Management of the placenta accreta spectrum is reviewed separately. (See "Placenta accreta spectrum: Management".)

Placenta previa — Management of the placenta previa is reviewed separately. (See "Placenta previa: Management".)

POST-LAPAROTOMY INSPECTION — At the completion of the laparotomy and before closing the abdomen, the operative field should be inspected carefully for hemostasis.

Microvascular bleeding usually can be controlled using topical hemostatic agents (table 2) (see "Overview of topical hemostatic agents and tissue adhesives", section on 'Choice of agent'). Clinicians should be familiar with the products available at their facility. We generally start with a cellulose-based surgical mesh (eg, Surgicell or Nuknit), which usually controls slow oozing. If a product that has an expansion property is desired, we will move to a collagen-based product such as Gelfoam. A more reactive product that has fibrin and thrombin can also be employed; we reserve this for more active bleeding because it is impregnated with clotting factors that combine to form an active seal that is more robust than simply providing a cellulose matrix for normal coagulation. For small areas (or those that are difficult to reach), we spray on powdered forms of cellulose such Avatene or Surgicell powder, and in some cases we may use a thrombin spray or a liquid such as Tisseal or Surgi-flow. There are significant cost differentials among these products, which should be considered and discussed with the pharmacy. If exposure to porcine-derived products is a consideration, the product insert will state the origin of the sealant.

The bladder and ureters should be identified and inspected. The ureter courses horizontally along the peritoneum 1 to 5 cm dorsal to the ovarian vessels and can be identified readily as it passes ventral to the bifurcation of the common iliac artery. Identification of bladder and/or ureteral injury is the same as during gynecologic surgery (ie, visual inspection, possible cystoscopy, dye injection, stent placement to assess for obstruction, ureterography). (See "Urinary tract injury in gynecologic surgery: Identification and management".)

ROLE OF HYSTERECTOMY — Hysterectomy is a definitive treatment of uterine bleeding. Regardless of the etiology of postpartum hemorrhage (PPH), continued blood loss can lead to severe coagulopathy due to massive loss of coagulation factors. Severe hypovolemia, tissue hypoxia, hypothermia, electrolyte abnormalities, and acidosis can result, which further compromise the patient's status. If the patient is not already at laparotomy and has developed these additional complications, then correction of the severe physiological deficits before hysterectomy, if possible, could be life-saving. (See "Peripartum hysterectomy for management of hemorrhage".)

In patients with placenta accreta spectrum or uterine rupture, early resort to hysterectomy may be the least morbid approach for controlling hemorrhage and may prevent deaths and morbidity caused by delays while ineffective fertility-preserving procedures are attempted. With improving prenatal diagnosis of placental attachment disorders, hysterectomy can often be anticipated and discussed with the patient before planned cesarean birth. (See "Placenta accreta spectrum: Clinical features, diagnosis, and potential consequences" and "Placenta accreta spectrum: Management".)

By contrast, uterine atony can usually be controlled by uterotonic medications alone or in combination with fertility-preserving procedures (eg, uterine compression sutures, uterine artery/utero-ovarian artery ligation, arterial embolization, intrauterine balloon tamponade), as described above. Once the patient is resuscitated and the coagulopathy is reversed, hysterectomy may no longer be required to control hemorrhage. However, if fertility-preserving procedures do not reduce the bleeding to a manageable level, then there is no choice but to proceed with hysterectomy.

Damage control approach for persistent bleeding after hysterectomy — Patients with continued severe bleeding after hysterectomy can enter a lethal downward spiral characterized by hypothermia, coagulopathy, and metabolic acidosis [56,57]. Criteria proposed for this "in extremis" state include pH <7.30, temperature <35°C, combined resuscitation and procedural time >90 minutes, nonmechanical bleeding, and transfusion requirement >10 units packed red blood cells (RBCs) [58].

To abort the cycle, the bleeding area is tightly packed, and the skin is closed to prevent heat and moisture loss (either with large sutures or with towel clamps). Placement of a large bore drainage catheter (such as a large Jackson-Pratt drain or a chest tube) in the pelvis at the time of temporary closure will allow early recognition of the need to return to the operating room.

Variations of the abdominal packing procedure have been published ("umbrella pack") [59-67]. One such variation is to fill a sterile plastic bag (eg, drawstring bag used to cover radiographic film) or cloth container with gauze (wet gauze gives it more weight) and place it against the pelvic bleeders. The drawstrings are pulled through the vagina and attached to a weight, which provides traction so that the pack exerts pressure against the pelvic floor.

A balloon tamponade device has also been used as a pelvic pressure pack after hysterectomy for PPH [68,69].

Some surgeons also use hemostatic agents (table 2), which may be applied directly to the bleeding tissue or included in pads for pelvic tamponade [70].

While there is no consensus on use of broad-spectrum prophylactic antibiotics while the pack is in place, this author gives them because these patients frequently have had emergency measures applied and have had potential breaks in sterility.

Some authorities favor the use of negative-pressure vacuum devices, where available, in patients undergoing temporary abdominal wall closure [71]. These devices can continuously collect fluid from the wound and abdominal cavity without damaging viscera because a protective layer is placed between the viscera and the device. For example, negative pressure can be applied to the dressing after the surgical team packs, covers, and seals the open abdomen. No study has specifically addressed prophylactic negative pressure wound therapy in patients who have persistent bleeding after hysterectomy for PPH. Use of the device in surgical and trauma patients has been associated with improved 30-day survival and higher rates of 30-day primary fascial closure [72]. (See "Negative pressure wound therapy".)

Under most circumstances, the patient should remain in the operating room with continuous monitoring, while replacement of appropriate blood products and correction of physiologic derangements ("damage control") occur [56,58]. This approach halts the downward spiral and lessens the risk of abdominal compartment syndrome, which is more likely if the fascia is closed. Abdominal compartment syndrome is more difficult to define postpartum since postcesarean intra-abdominal pressure appears to be higher than in the general surgical population, especially in patients with elevated body mass index and hypertensive disorders [73-76]. (See "Abdominal compartment syndrome in adults".)

The patient can leave the operating room after they have been stabilized, as evidenced by cessation of active bleeding, maintenance of hemodynamic stability, and satisfactory progress in the management/reversal of any coagulopathy. Depending on the degree of blood loss, the amount of resuscitation required, the risk of resumption of bleeding, and the need for ventilation, they can be transferred to a high-care post-anesthesia care unit (PACU) or an intensive care unit (ICU) for one-to-one nursing and close observation by the physician team as appropriate.

The need for ≥2 units packed RBCs per hour for three hours is a sign of significant ongoing bleeding and need to return to the operating room or arterial embolization by an interventional vascular specialist. In one study, bleeding did not stop in 20 of 53 patients despite abdominal packing; six required a second surgical intervention, six underwent pelvic artery embolization, and eight had further intensive resuscitation and pharmacologic treatments [67].

Patients who have been stabilized are returned to the operating room to undergo definitive surgical care in approximately 48 hours. Packing should not be removed until coagulation defects have been corrected. If the packing has controlled bleeding, it generally is removed at this time. If it is removed too soon (<24 hours), bleeding will resume, whereas if it is removed too late (>72 hours), pelvic infection or abscess may ensue.

Under general anesthesia, the wound is opened and the gauze is removed with gentle traction. The pelvis is irrigated with saline to clear loose clots and other debris, but aggressive exploration of the pelvis is not performed if no pooling of blood is noted. The wound is then reapproximated in the usual manner.

General principles of damage control surgery in severely injured patients are reviewed separately (see "Overview of damage control surgery and resuscitation in patients sustaining severe injury"). Supportive care for critically ill postpartum patients is also discussed separately. (See "Critical illness during pregnancy and the peripartum period", section on 'Supportive care'.)

ROLE OF EMBOLIZATION — The main settings when embolization may be indicated are:

At laparotomy, when persistent non-life-threatening deep pelvic bleeding occurs after repair of lacerations or hysterectomy and cannot be controlled by surgical ligation or ablation.

Embolization is an option if the facility has an appropriately equipped operating room (hybrid operating room, or an appropriately sensitive portable C-arm and carbon fiber table).

After laparotomy, when persistent slow internal bleeding is suspected in a hemodynamically stable patient. The patient can be transferred to the interventional radiology suite for a diagnostic angiogram and embolization (if a bleeding source is seen).

Hemodynamically unstable patients should be evaluated in the operating room, not the interventional radiology suite. If the facility has an appropriately equipped operating room, performing uterine or internal iliac artery embolization in an operating room with the full surgical team in attendance is an option. Laparotomy is performed if the patient deteriorates during evaluation and embolization or if the embolization fails.

In patients with a placenta accreta spectrum. Embolization can reduce bleeding before and during hysterectomy or when conservative management (leaving the placenta in situ) is attempted. Direct arterial puncture of the internal iliac artery and embolization at cesarean birth has been described in 16 cases of placenta accreta spectrum [77]. The procedure was successful in all of the cases and no complications (eg, fever, buttock pain, acute limb ischemia) occurred. (See "Placenta accreta spectrum: Management", section on 'Endovascular intervention for hemorrhage control'.)

Embolization after a failed uterine artery ligation is more difficult [78,79], although not impossible. In one study, arterial embolization was successful in 10 of 11 cases of failed surgical ligation therapy for postpartum hemorrhage (PPH) [80]. Thus, uterine artery embolization can be considered an option even after failed surgical ligation due to incomplete/ineffective occlusion. (See "Postpartum hemorrhage: Medical and minimally invasive management", section on 'Consider uterine or hypogastric artery embolization'.)

SOCIETY GUIDELINE LINKS — Links to society and government-sponsored guidelines from selected countries and regions around the world are provided separately. (See "Society guideline links: Obstetric hemorrhage".)

INFORMATION FOR PATIENTS — UpToDate offers two types of patient education materials, "The Basics" and "Beyond the Basics." The Basics patient education pieces are written in plain language, at the 5th to 6th grade reading level, and they answer the four or five key questions a patient might have about a given condition. These articles are best for patients who want a general overview and who prefer short, easy-to-read materials. Beyond the Basics patient education pieces are longer, more sophisticated, and more detailed. These articles are written at the 10th to 12th grade reading level and are best for patients who want in-depth information and are comfortable with some medical jargon.

Here are the patient education articles that are relevant to this topic. We encourage you to print or e-mail these topics to your patients. (You can also locate patient education articles on a variety of subjects by searching on "patient info" and the keyword(s) of interest.)

Basics topic (see "Patient education: Postpartum hemorrhage (The Basics)")

SUMMARY AND RECOMMENDATIONS

Abdominal incision – For patients in whom the abdomen is not already open for cesarean birth, we suggest a midline abdominal incision for treatment of postpartum hemorrhage (PPH). For those undergoing or with completed cesarean delivery, extension of the existing incision is more appropriate. (See 'Evaluation of the abdomen' above.)

Temporizing measures – In hemodynamically unstable patients, temporizing maneuvers to reduce bleeding should be attempted prior to performing surgical procedures that take significant time to control hemorrhage. The option chosen depends on the urgency to control bleeding, the source of bleeding (intrauterine versus extrauterine), and the surgeon's expertise and preference:

Manual aortic compression (in highly urgent settings) (see 'Manual aortic compression' above)

Uterine tourniquet (see 'Uterine tourniquet' above)

Intrauterine balloon tamponade (see 'Intrauterine balloon tamponade' above)

Ligation of the uterine and utero-ovarian arteries (see 'Ligation of uterine and utero-ovarian arteries' above)

Pelvic pack (see 'Pelvic packing' above)

Clamp across utero-ovarian ligaments (note: will occlude fallopian tubes) (see 'Clamp across utero-ovarian ligaments' above)

Internal iliac artery ligation (procedure of last resort) (see 'Role of internal iliac (hypogastric) artery ligation' above)

Intraoperative blood salvage – Intraoperative blood salvage may be arranged before laparotomy or requested during laparotomy, but its use is investigational in the obstetric setting. (See 'Role of intraoperative cell salvage' above.)

Treatment approaches based on bleeding site

Hysterotomy bleeding – Bleeding from a hysterotomy incision can generally be controlled by suture ligation. The angles of a transverse incision should be clearly visualized to ensure that they, and any retracted vessels, are completely ligated. If possible, the ipsilateral ureter should be identified before the bleeding is controlled and, once the hemorrhage has been controlled, the integrity of the ureter should be ensured. (See 'Myometrial lacerations' above.)

Branch artery bleeding – Bilateral ligation of the uterine vessels (O'Leary stitch) is the preferred approach for controlling PPH from laceration of the uterine artery or branches of the utero-ovarian artery. If this does not control bleeding, the vessels of the utero-ovarian arcade are similarly ligated. (See 'Laceration of the uterine artery or utero-ovarian artery branches' above.)

Atony – The interventions for reduction and control of bleeding due to atony are applied in rapid sequence until bleeding is controlled, which may be the result of the cumulative combined effect of multiple interventions. If uterine atony persists despite uterine massage and administration of uterotonic medications and tranexamic acid, we suggest rapidly moving on to placement of uterine compression sutures, which are an effective method for reducing uterine blood loss related to atony. Manual compression of the uterus, insertion of an intrauterine balloon for tamponade, placement of a uterine tourniquet, and/or ligation of the uterine and utero-ovarian arteries can reduce brisk ongoing heavy blood loss before placement of compression sutures. In some cases, hemorrhage will cease after one or more of these interventions and the compression sutures will not be needed. (See 'Atony' above.)

Retroperitoneal bleeding – Identification of an isolated bleeding point in the retroperitoneum is often impossible, so it is rarely advisable to open the retroperitoneum or attempt dissection of any nonexpanding retroperitoneal hematoma or an expanding retroperitoneal hematoma in a coagulopathic, hemodynamically unstable patient. Temporizing procedures can be used to stabilize the patient before beginning retroperitoneal surgery. (See 'Retroperitoneal bleeding' above.)

Placental site bleeding – Management of PPH from placental abnormalities, including preoperative placement of balloon catheters by an interventional vascular specialist, is reviewed separately. (See "Placenta previa: Management" and "Placenta accreta spectrum: Management".)

Candidates for hysterectomy and damage control – Early hysterectomy is appropriate in patients with severe bleeding due to diffuse placenta accreta/increta/percreta or a large uterine rupture. Hysterectomy is generally a last resort in patients with atony but should not be delayed in those who have severe coagulopathy and require prompt control of uterine hemorrhage to prevent severe morbidity or death. (See 'Role of hysterectomy' above.)

Patients with persistent severe hemorrhage after hysterectomy can enter a lethal downward spiral characterized by hypothermia, coagulopathy, and metabolic acidosis. To abort the cycle, the bleeding area is tightly packed, and the skin temporarily closed while the patient is actively warmed and resuscitated. The patient should not be moved from the operating room until the bleeding has been controlled and they are hemodynamically stable. The patient should then be transferred to an intensive care unit (ICU) for continuous monitoring, ongoing replacement of appropriate blood products, and correction of physiologic derangements. (See 'Damage control approach for persistent bleeding after hysterectomy' above.)

Candidates for embolization – The main settings when embolization may be indicated are (see 'Role of embolization' above):

At laparotomy, when persistent non-life-threatening deep pelvic bleeding occurs after repair of lacerations or hysterectomy and cannot be controlled by surgical ligation or ablation. Embolization is only an option if the facility has an appropriately equipped operating room (hybrid operating room, or an appropriately sensitive portable C-arm and carbon fiber table).

After laparotomy, when persistent slow internal bleeding is suspected in a hemodynamically stable patient. The stable patient can be transferred to the interventional radiology suite for a diagnostic angiogram and embolization (if a bleeding source is seen).

Hemodynamically unstable patients should be evaluated in the operating room, not the interventional radiology suite. Interventional procedures can only be used in this clinical situation if the facility has an appropriately equipped operating room. Laparotomy is performed if the patient deteriorates during evaluation and embolization or the embolization fails.

In patients with placenta accreta spectrum. (See "Placenta accreta spectrum: Management".)

ACKNOWLEDGMENT — The UpToDate editorial staff acknowledges Dr. Allan J Jacobs, who contributed to earlier versions of this topic review.

  1. Chen L, Wang X, Wang H, et al. Clinical evaluation of prophylactic abdominal aortic balloon occlusion in patients with placenta accreta: a systematic review and meta-analysis. BMC Pregnancy Childbirth 2019; 19:30.
  2. Ribeiro Junior MAF, Feng CYD, Nguyen ATM, et al. The complications associated with Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA). World J Emerg Surg 2018; 13:20.
  3. Søvik E, Stokkeland P, Storm BS, et al. The use of aortic occlusion balloon catheter without fluoroscopy for life-threatening post-partum haemorrhage. Acta Anaesthesiol Scand 2012; 56:388.
  4. Harma M, Harma M, Kunt AS, et al. Balloon occlusion of the descending aorta in the treatment of severe post-partum haemorrhage. Aust N Z J Obstet Gynaecol 2004; 44:170.
  5. Taylor A, Sharma M, Tsirkas P, et al. Reducing blood loss at open myomectomy using triple tourniquets: a randomised controlled trial. BJOG 2005; 112:340.
  6. Breen M. Temporary treatment of severe postpartum hemorrhage. Int J Gynaecol Obstet 2012; 118:253.
  7. Luotonen J. [Management of epistaxis]. Duodecim 1987; 103:101.
  8. Doumouchtsis SK, Nikolopoulos K, Talaulikar V, et al. Menstrual and fertility outcomes following the surgical management of postpartum haemorrhage: a systematic review. BJOG 2014; 121:382.
  9. Joshi VM, Otiv SR, Majumder R, et al. Internal iliac artery ligation for arresting postpartum haemorrhage. BJOG 2007; 114:356.
  10. Evans S, McShane P. The efficacy of internal iliac artery ligation in obstetric hemorrhage. Surg Gynecol Obstet 1985; 160:250.
  11. Buckley B. Interventional radiology in abnormal placentation. RANZCOG O & G Magazine 2010; 12:56. https://www.google.com/search?q=Buckley+B.+Interventional+radiology+in+abnormal+placentation.+RANZCOG+O+%26+G+Magazine+2010%3B+12%3B56.&sourceid=ie7&rls=com.microsoft:en-US:IE-Address&ie=&oe=&gws_rd=ssl (Accessed on July 01, 2017).
  12. Dubreuil-Chambardel L. Traite des variations du system arteriel variations des arteres du pelvis et du membre inferieur, Masson et Cie, Paris 1925.
  13. Khan KS, Moore PAS, Wilson MJ, et al. Cell salvage and donor blood transfusion during cesarean section: A pragmatic, multicentre randomised controlled trial (SALVO). PLoS Med 2017; 14:e1002471.
  14. Lim G, Melnyk V, Facco FL, et al. Cost-effectiveness Analysis of Intraoperative Cell Salvage for Obstetric Hemorrhage. Anesthesiology 2018; 128:328.
  15. Albright CM, Rouse DJ, Werner EF. Cost savings of red cell salvage during cesarean delivery. Obstet Gynecol 2014; 124:690.
  16. Committee on Practice Bulletins-Obstetrics. Practice Bulletin No. 183: Postpartum Hemorrhage. Obstet Gynecol 2017; 130:e168.
  17. Rebarber A, Lonser R, Jackson S, et al. The safety of intraoperative autologous blood collection and autotransfusion during cesarean section. Am J Obstet Gynecol 1998; 179:715.
  18. Rainaldi MP, Tazzari PL, Scagliarini G, et al. Blood salvage during caesarean section. Br J Anaesth 1998; 80:195.
  19. Liumbruno GM, Meschini A, Liumbruno C, Rafanelli D. The introduction of intra-operative cell salvage in obstetric clinical practice: a review of the available evidence. Eur J Obstet Gynecol Reprod Biol 2011; 159:19.
  20. Liumbruno GM, Liumbruno C, Rafanelli D. Intraoperative cell salvage in obstetrics: is it a real therapeutic option? Transfusion 2011; 51:2244.
  21. Hubbard RM, Waters JH, Yazer MH. Successful Resuscitation Following Massive Obstetric Hemorrhage in a Patient of the Jehovah's Witness Faith: A Case Report. A A Case Rep 2017; 8:326.
  22. Yan H, Hu LQ, Wu Y, et al. The Association of Targeted Cell Salvage Blood Transfusion During Cesarean Delivery With Allogeneic Packed Red Blood Cell Transfusions in a Maternity Hospital in China. Anesth Analg 2018; 127:706.
  23. Oei SG, Winger CB, Kerkkamp HE, et al. Cell salvage: how safe in obstetrics. Int J Obstet Anesth 2000; 9:143.
  24. Milne ME, Yazer MH, Waters JH. Red blood cell salvage during obstetric hemorrhage. Obstet Gynecol 2015; 125:919.
  25. O'Leary JL, O'Leary JA. Uterine artery ligation in the control of intractable postpartum hemorrhage. Am J Obstet Gynecol 1966; 94:920.
  26. O'Leary JA. Uterine artery ligation in the control of postcesarean hemorrhage. J Reprod Med 1995; 40:189.
  27. AbdRabbo SA. Stepwise uterine devascularization: a novel technique for management of uncontrolled postpartum hemorrhage with preservation of the uterus. Am J Obstet Gynecol 1994; 171:694.
  28. Sentilhes L, Trichot C, Resch B, et al. Fertility and pregnancy outcomes following uterine devascularization for severe postpartum haemorrhage. Hum Reprod 2008; 23:1087.
  29. Roman H, Sentilhes L, Cingotti M, et al. Uterine devascularization and subsequent major intrauterine synechiae and ovarian failure. Fertil Steril 2005; 83:755.
  30. Kayem G, Kurinczuk JJ, Alfirevic Z, et al. Uterine compression sutures for the management of severe postpartum hemorrhage. Obstet Gynecol 2011; 117:14.
  31. Gottlieb AG, Pandipati S, Davis KM, Gibbs RS. Uterine necrosis: a complication of uterine compression sutures. Obstet Gynecol 2008; 112:429.
  32. B-Lynch C. Partial ischemic necrosis of the uterus following a uterine brace compression suture. BJOG 2005; 112:126.
  33. Joshi VM, Shrivastava M. Partial ischemic necrosis of the uterus following a uterine brace compression suture. BJOG 2004; 111:279.
  34. Reyftmann L, Nguyen A, Ristic V, et al. [Partial uterine wall necrosis following Cho hemostatic sutures for the treatment of postpartum hemorrhage]. Gynecol Obstet Fertil 2009; 37:579.
  35. El-Hamamy E. Partial ischemic necrosis of the uterus following a uterine brace compression suture. BJOG 2005; 112:126.
  36. Pechtor K, Richards B, Paterson H. Antenatal catastrophic uterine rupture at 32 weeks of gestation after previous B-Lynch suture. BJOG 2010; 117:889.
  37. Gizzo S, Saccardi C, Patrelli TS, et al. Fertility rate and subsequent pregnancy outcomes after conservative surgical techniques in postpartum hemorrhage: 15 years of literature. Fertil Steril 2013; 99:2097.
  38. Poujade O, Grossetti A, Mougel L, et al. Risk of synechiae following uterine compression sutures in the management of major postpartum haemorrhage. BJOG 2011; 118:433.
  39. B-Lynch C, Coker A, Lawal AH, et al. The B-Lynch surgical technique for the control of massive postpartum haemorrhage: an alternative to hysterectomy? Five cases reported. Br J Obstet Gynaecol 1997; 104:372.
  40. Ferguson JE, Bourgeois FJ, Underwood PB. B-Lynch suture for postpartum hemorrhage. Obstet Gynecol 2000; 95:1020.
  41. Allam MS, B-Lynch C. The B-Lynch and other uterine compression suture techniques. Int J Gynaecol Obstet 2005; 89:236.
  42. Sentilhes L, Gromez A, Razzouk K, et al. B-Lynch suture for massive persistent postpartum hemorrhage following stepwise uterine devascularization. Acta Obstet Gynecol Scand 2008; 87:1020.
  43. Smith KL, Baskett TF. Uterine compression sutures as an alternative to hysterectomy for severe postpartum hemorrhage. J Obstet Gynaecol Can 2003; 25:197.
  44. Fuglsang J. Later reproductive health after B-Lynch sutures: a follow-up study after 10 years' clinical use of the B-Lynch suture. Fertil Steril 2014; 101:1194.
  45. Cowan AD, Miller ES, Grobman WA. Subsequent pregnancy outcome after B-lynch suture placement. Obstet Gynecol 2014; 124:558.
  46. Hayman RG, Arulkumaran S, Steer PJ. Uterine compression sutures: surgical management of postpartum hemorrhage. Obstet Gynecol 2002; 99:502.
  47. Ghezzi F, Cromi A, Uccella S, et al. The Hayman technique: a simple method to treat postpartum haemorrhage. BJOG 2007; 114:362.
  48. Pereira A, Nunes F, Pedroso S, et al. Compressive uterine sutures to treat postpartum bleeding secondary to uterine atony. Obstet Gynecol 2005; 106:569.
  49. Ouahba J, Piketty M, Huel C, et al. Uterine compression sutures for postpartum bleeding with uterine atony. BJOG 2007; 114:619.
  50. Cho JH, Jun HS, Lee CN. Hemostatic suturing technique for uterine bleeding during cesarean delivery. Obstet Gynecol 2000; 96:129.
  51. Nelson GS, Birch C. Compression sutures for uterine atony and hemorrhage following cesarean delivery. Int J Gynaecol Obstet 2006; 92:248.
  52. Hackethal A, Brueggmann D, Oehmke F, et al. Uterine compression U-sutures in primary postpartum hemorrhage after Cesarean section: fertility preservation with a simple and effective technique. Hum Reprod 2008; 23:74.
  53. Zheng J, Xiong X, Ma Q, et al. A new uterine compression suture for postpartum haemorrhage with atony. BJOG 2011; 118:370.
  54. Nanda S, Singhal SR. Hayman uterine compression stitch for arresting atonic postpartum hemorrhage: 5 years experience. Taiwan J Obstet Gynecol 2011; 50:179.
  55. Alouini S, Coly S, Mégier P, et al. Multiple square sutures for postpartum hemorrhage: results and hysteroscopic assessment. Am J Obstet Gynecol 2011; 205:335.e1.
  56. Hess JR, Lawson JH. The coagulopathy of trauma versus disseminated intravascular coagulation. J Trauma 2006; 60:S12.
  57. Rotondo MF, Zonies DH. The damage control sequence and underlying logic. Surg Clin North Am 1997; 77:761.
  58. Sagraves SG, Toschlog EA, Rotondo MF. Damage control surgery--the intensivist's role. J Intensive Care Med 2006; 21:5.
  59. Dildy GA, Scott JR, Saffer CS, Belfort MA. An effective pressure pack for severe pelvic hemorrhage. Obstet Gynecol 2006; 108:1222.
  60. Finan MA, Fiorica JV, Hoffman MS, et al. Massive pelvic hemorrhage during gynecologic cancer surgery: "pack and go back". Gynecol Oncol 1996; 62:390.
  61. Ghourab S, Al-Nuaim L, Al-Jabari A, et al. Abdomino-pelvic packing to control severe haemorrhage following caesarean hysterectomy. J Obstet Gynaecol 1999; 19:155.
  62. Awonuga AO, Merhi ZO, Khulpateea N. Abdominal packing for intractable obstetrical and gynecologic hemorrhage. Int J Gynaecol Obstet 2006; 93:160.
  63. Howard RJ, Straughn JM Jr, Huh WK, Rouse DJ. Pelvic umbrella pack for refractory obstetric hemorrhage secondary to posterior uterine rupture. Obstet Gynecol 2002; 100:1061.
  64. Robie GF, Morgan MA, Payne GG Jr, Wasemiller-Smith L. Logothetopulos pack for the management of uncontrollable postpartum hemorrhage. Am J Perinatol 1990; 7:327.
  65. Hallak M, Dildy GA 3rd, Hurley TJ, Moise KJ Jr. Transvaginal pressure pack for life-threatening pelvic hemorrhage secondary to placenta accreta. Obstet Gynecol 1991; 78:938.
  66. Dildy GA, Scott JR, Saffer CS, Belfort MA. Pelvic pressure pack for catastrophic postpartum hemorrhage. Obstet Gynecol 2000; 95:S7.
  67. Deffieux X, Vinchant M, Wigniolle I, et al. Maternal outcome after abdominal packing for uncontrolled postpartum hemorrhage despite peripartum hysterectomy. PLoS One 2017; 12:e0177092.
  68. Dildy GA, Belfort MA, Adair CD, et al. Initial experience with a dual-balloon catheter for the management of postpartum hemorrhage. Am J Obstet Gynecol 2014; 210:136.e1.
  69. Charoenkwan K. Effective use of the Bakri postpartum balloon for posthysterectomy pelvic floor hemorrhage. Am J Obstet Gynecol 2014; 210:586.e1.
  70. Choron RL, Hazelton JP, Hunter K, et al. Intra-abdominal packing with laparotomy pads and QuikClot™ during damage control laparotomy: A safety analysis. Injury 2017; 48:158.
  71. Pacheco LD, Lozada MJ, Saade GR, Hankins GDV. Damage-Control Surgery for Obstetric Hemorrhage. Obstet Gynecol 2018; 132:423.
  72. Cheatham ML, Demetriades D, Fabian TC, et al. Prospective study examining clinical outcomes associated with a negative pressure wound therapy system and Barker's vacuum packing technique. World J Surg 2013; 37:2018.
  73. Abdel-Razeq SS, Campbell K, Funai EF, et al. Normative postpartum intraabdominal pressure: potential implications in the diagnosis of abdominal compartment syndrome. Am J Obstet Gynecol 2010; 203:149.e1.
  74. Tyagi A, Singh S, Kumar M, Sethi AK. Intra-abdominal pressure and intra-abdominal hypertension in critically ill obstetric patients: a prospective cohort study. Int J Obstet Anesth 2017; 32:33.
  75. Fuchs F, Bruyere M, Senat MV, et al. Are standard intra-abdominal pressure values different during pregnancy? PLoS One 2013; 8:e77324.
  76. Chun R, Kirkpatrick AW. Intra-abdominal pressure, intra-abdominal hypertension, and pregnancy: a review. Ann Intensive Care 2012; 2 Suppl 1:S5.
  77. Chen Z, Li J, Shen J, et al. Direct puncture embolization of the internal iliac artery during cesarean delivery for pernicious placenta previa coexisting with placenta accreta. Int J Gynaecol Obstet 2016; 135:264.
  78. Mason BA. Postpartum hemorrhage and arterial embolization. Curr Opin Obstet Gynecol 1998; 10:475.
  79. Vedantham S, Goodwin SC, McLucas B, Mohr G. Uterine artery embolization: an underused method of controlling pelvic hemorrhage. Am J Obstet Gynecol 1997; 176:938.
  80. Sentilhes L, Gromez A, Clavier E, et al. Predictors of failed pelvic arterial embolization for severe postpartum hemorrhage. Obstet Gynecol 2009; 113:992.
Topic 6712 Version 77.0

References