Several "lacunar cells" are present. They are characterized by multilobated nuclei, small nucleoli, and abundant, pale cytoplasm that often "retracts" during tissue fixation and sectioning, leaving the nucleus in what appears to be an empty space (lacune). "Mummified cells" are neoplastic cells that contain condensed cytoplasm and pyknotic reddish nuclei. A "mummified" Reed-Sternberg cell is in the upper left corner.
Reproduced with permission from: Weiss LM, Warnke RA, Hansmann ML, et al. Pathology of Hodgkin Lymphoma. In: Hodgkin Lymphoma, 2nd ed, Hoppe RT, Mauch PT, Armitage JO, et al (Eds), Lippincott Williams & Wilkins, Philadelphia 2007. Copyright © 2007 Lippincott Williams & Wilkins.
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