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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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TREE 1 and TREE 2 trials: comparing best response and toxicity in metastatic colorectal cancer

TREE 1 and TREE 2 trials: comparing best response and toxicity in metastatic colorectal cancer
  Percent of patients
FOLFOX6* bFOL CAPOX
TREE 1 (n = 49) TREE 2 (n = 71) TREE 1 (n = 50) TREE 2 (n = 70) TREE 1Δ (n = 48) TREE 2Δ (n = 72)
Response rate◊ 41 52 20 39 27 46
Time to tumor progression, months◊ 8.7 9.9 6.9 8.3 5.9 10.3
Overall survival, months◊ 19.2 26.1 17.9 20.4 17.2 24.6
Grade 3 to 4 toxicity, percent
Vomiting or nausea 31 7 24 24 38 21
Diarrhea 31 11 26 26 31 19
Neutropenia 53 49 18 19 15 10
Hand-foot syndrome 8 0 2 0 19 10
Sensory neurotoxicity 18 11 10 9 21 11
Hypertension 0 7 0 13 2 15
Deep vein thrombosis 6 4 2 1 0 3
* FOLFOX6: oxaliplatin 85 mg/m2 on day 1, leucovorin 400 mg/m2 over two hours day 1, FU 400 mg/m2 bolus day 1 followed by 2400 mg/m2 over 46 hours, every 14 days; bFOL: Oxaliplatin 85 mg/m2 days 1 and 15 plus leucovorin 20 mg/m2 and bolus FU 500 mg/m2 days 1, 8, and 15 every 28 days; CAPOX: Oxaliplatin 130 mg/m2 day 1, capecitabine 1000 mg/m2 (850 mg/m2 for TREE 2) for 14 days every 21 days.
¶ TREE 2 trial added bevacizumab 5 mg/kg every other week.
Δ Capecitabine dose differed in TREE 1 (1000 mg/m2 twice daily for 14 of every 21 days) and TREE 2 (850 mg/m2 twice daily for 14 of every 21 days).
◊ J Clin Oncol 2008; 26:3523.
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