Frequency of decreased IgG subclass concentrations in different populations

Sample population	Number	Percent
Sample population	Number	IgG1	IgG2	IgG3	IgG4
Healthy children	3854	4.9	19.4	6.3	0.8
Healthy adults	162	8	3	1	1
Adults with suspected antibody defects	1175	28	17	13	9

Data from different populations showing the percentage of individuals with low serum levels of specific IgG subclasses.

IgG: immunoglobulin G.

Reproduced with permission from: Meulenbroek AJ, Zeijlemaker WP. Human IgG subclasses: Useful diagnostic markers for immunocompetence, 2nd edition, CLB, Amsterdam, The Netherlands 2000. Copyright © 2000 Sanquin Blood Supply Foundation.

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