Leukocyte-adhesion deficiency syndromes

	LAD I	LAD II	LAD III
Clinical manifestation
Recurrent severe infections	+++	+	+++
Neutrophilia
basal	+	+++	++
with infection	+++	+++	+++
Periodontitis	++	++	?
Skin infection	++	+	++
Delayed separation of the umbilical cord	+++	-	+
Developmental abnormalities	-	+++
Bleeding tendency	-	-	+++
Laboratory findings
CD18 expression	↓ ↓ ↓ or absent	NL	NL
SLeX expression	NL	Absent	NL
Neutrophil motility	↓ ↓ ↓	↓ ↓	↓ ↓
Neutrophil rolling	NL	↓ ↓ ↓	NL
Neutrophil adherence	↓ ↓ ↓	↓	↓ ↓ ↓
Opsonophagocytic activity	↓	NL	NL
T and B cell function	↓	NL	?

LAD: leukocyte-adhesion deficiency; CD18: common beta-2 subunit of the beta-2 leukocyte integrins; SLeX: sialyl Lewis X; NL: normal.

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