CHOP chemotherapy for non-Hodgkin lymphoma

CHOP-21 chemotherapy consists of four agents: Cyclophosphamide (Cytoxan), Doxorubicin (Adriamycin, Hydroxydaunomycin), Vincristine (Oncovin), and Prednisone. One complete course is given every 21 days. Full treatment usually consists of six to eight such courses.
Drug	Dose and route^[1,2]	Given on day(s)
Cyclophosphamide	750 mg/m² IV	Day 1
Doxorubicin	50 mg/m² IV	Day 1
Vincristine	1.4 mg/m² IV (maximum 2 mg)	Day 1
Prednisone	100 mg per day orally	Days 1 through 5

References:

McKelvey EM, Gottlieb JA, Wilson HE, et al. Hydroxyldaunomycin (Adriamycin®) combination chemotherapy in malignant lymphoma. Cancer 1976; 38:1484.
Fisher RI, Gaynor ER, Dahlberg S, et al. Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma. N Engl J Med 1993; 328:1002.

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