Grade 3 or worse chemotherapy toxicity in fit older patients

Toxicity in percent	Regimen
	FOLFOX^[1]		Irinotecan/FU/LV^[2]		FU/LV^[2]		FU/LV^[3]
	≥70 years	<70 years	≥70 years	<70 years	≥70 years	<70 years	≥70 years	<70 years
Leukopenia	-	-	19	17	6	7	8*	4
Neutropenia	49*	43	30	29	20	16	-	-
Infection	4	5	2	1	3	1	-	-
Thrombocytopenia	5*	2	1	2	1	1	-	-
Stomatitis	-	-	4	3	4	3	15	11
Diarrhea	13	11	23	21	13	11	15	15
Nausea/vomiting	7	9	11/10	11/10	4/3	6/5	2	5
Fatigue	7	4	-	-	-	-	-	-
Neurotoxicity	12	14	-	-	-	-	-	-

Gr3_chemo_tox_elderly_pts.htm

-: not reported; FU: fluorouracil; LV: leucovorin.
* p value ≥70 versus <70 statistically significant.

1. Goldberg, R, et al. J Clin Oncol 2006; 24:4085.
2. Folprecht, J, et al. J Clin Oncol 2008; 26:1443.
3. Sargent, D, et al. N Engl J Med 2001; 345:1091.

Graphic 66108 Version 2.0

خرید پکیج

Grade 3 or worse chemotherapy toxicity in fit older patients