Major causes of chronic secretory diarrhea*

Factitious diarrhea (laxative abuse)

Rectal villous adenoma

Neuroendocrine tumors

VIPoma

Carcinoid syndrome

Gastrinoma (Zollinger-Ellison syndrome)

Lymphocytic or collagenous colitis

Congenital diarrhea

Bile salt enteropathy

Enterotoxic Escherichia coli

* Secretory diarrhea is defined as diarrhea associated with a stool osmolal gap less than 50 mosmol/kg.

Modified from: Donowitz M, Kokke FT, Saidi R. Evaluation of patients with chronic diarrhea. N Engl J Med 1995; 332:725.

Graphic 65916 Version 6.0

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