Risk assessment criteria for inherited breast-ovarian cancer syndome, combining several guidelines

Non-Jewish families

Any of the following:

1 case of breast cancer ≤40 years old in a first- or second-degree relative

1 first- or second-degree relative with breast and ovarian cancer, at any age

2 or more cases of breast cancer in first- or second-degree relatives if one is diagnosed at ≤50 years old or is bilateral cancer

1 first- or second-degree relative with breast cancer at ≤50 years old, or bilateral breast cancer, and 1 first- or second-degree relative with ovarian cancer

3 cases of breast and ovarian cancer (at least 1 case of ovarian cancer) in first- or second-degree relatives

2 cases of ovarian cancer in first- or second-degree relatives

1 case of male breast cancer in a first- or second-degree relative if another first- or second-degree relative has (male or female) breast or ovarian cancer

Jewish families

Any of the following:

1 or more cases of breast cancer ≤50 years old in a first- or second-degree relative

1 or more cases of ovarian cancer at any age in a first- or second-degree relative

1 or more first- or second-degree relatives with breast cancer at any age, if another first- or second-degree relative has breast and/or ovarian cancer at any age

1 or more cases of male breast cancer in a first- or second-degree relative

Adapted from: Hampel H, Sweet K, Westman JA, et al. Referral for cancer genetics consultation: a review and compilation of risk assessment criteria. J Med Genet 2004; 41:81.

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خرید پکیج

Risk assessment criteria for inherited breast-ovarian cancer syndome, combining several guidelines