Alterations of lymphocyte populations in some defined immunodeficiencies

SCID: severe combined immunodeficiency; JAK3: Janus kinase 3; IL-7R-alpha: interleukin 7 receptor alpha chain (CD127) defect; ADA: adenosine deaminase; PNP: purine nucleoside phosphorylase; MHC: major histocompatibility complex; CD3 deficiency: deficiency of a component of CD3 (gamma, epsilon); ZAP-70: CD3 zeta-associated 70 kd tyrosine kinase; NK: primary natural killer cell; XLA: X-linked agammaglobulinemia; WAS: Wiskott-Aldrich syndrome; AT: ataxia-telangiectasia; CVID: common variable immunodeficiency; nl: normal; p: progressive over time; DNA: deoxyribonucleic acid.

* The percentage of NK cells may be increased due to the absence of the subset principally affected in the disease. The absolute NK cell number is generally normal.