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NCI CTCAE v5.0 hematologic toxicity

NCI CTCAE v5.0 hematologic toxicity
Blood element Grade 1 Grade 2 Grade 3 Grade 4 Grade 5
Neutrophils <LLN to 1500/microL 1000 to 1500/microL 500 to 1000/microL <500/microL  
Platelets <LLN to 75,000/microL 50,000 to 75,000/microL 25,000 to 50,000/microL <25,000/microL  
Hemoglobin <LLN to 10 g/dL 8.0 to 10.0 g/dL <8.0 g/dL Life-threatening consequences; urgent intervention indicated Death
Lymphocytes (total) <LLN to 800/microL 500 to 800/microL 200 to 500/microL <200/microL  
CD4 count <LLN to 500/microL 200 to 500/microL 50 to 200/microL <50/microL  
Febrile neutropenia     ANC <1000/microL with a single temperature >38.3°C (100.4°F) or a sustained temperature ≥38°C (100°F) for more than one hour Life-threatening consequences; urgent intervention indicated Death
Neutropenia, thrombocytopenia, anemia, and lymphocytopenia are determined from the complete blood count. All patients with fever in the setting of chemotherapy-induced neutropenia require immediate medical attention regardless of the toxicity grade. Refer to UpToDate topics on febrile neutropenia regarding the management of these patients.
NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events; LLN: lower limit of normal; ANC: absolute neutrophil count. Cells/microL is equivalent to cells/mm3 or cells x 109/L.
Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed March 27, 2018).
Graphic 64984 Version 15.0

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