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Comparison of conjugate vaccines against Haemophilus influenzae type b licensed in the United States

Comparison of conjugate vaccines against Haemophilus influenzae type b licensed in the United States
Vaccine
(commercial name)		 Carrier protein Recommended age of administration* Allergy considerations
Monovalent Hib vaccines

PRP-OMP

(PedvaxHIB)

 Outer membrane protein complex of Neisseria meningitidis 2, 4, and 12 through 15 months Vial stoppers contain natural rubber latex
PRP-T
(ActHIB)		 Tetanus toxoid 2, 4, 6, and 12 through 15 months Vial stoppers contain natural rubber latex
PRP-T
(Hiberix)		 Tetanus toxoid 2, 4, 6, and 12 through 15 months Vial stoppers do not contain natural rubber latex
Combination Hib vaccine
DTaP-IPV/PRP-T
(Pentacel)		 Tetanus toxoid 2, 4, 6, and 15 through 18 monthsΔ Vial stoppers do not contain natural rubber latex
DTaP, IPV, Hib, and HepB (Vaxelis)

Outer membrane protein complex of N. meningitidis

 2, 4, and 6 months of age Vial stoppers do not contain natural rubber latex
Hib: H. influenzae type b; PRP-OMP: polyribosylribitol phosphate conjugated to outer membrane protein complex of N. meningitidis; PRP-T: polyribosylribitol phosphate conjugated to tetanus toxoid; DTaP: diphtheria toxoid-tetanus toxoid-acellular pertussis vaccine; IPV: inactivated polio vaccine; HepB: hepatitis B vaccine.
* The first dose may be given as early as six weeks of age.
¶ Preferred for Native Americans and Alaskan natives.
Δ The booster (ie, fourth) dose may be given as early as 12 months of age, provided at least six months have elapsed since the third dose of DTaP.
Data from:
1. Briere EC, Rubin L, Moro PL, et al. Prevention and control of Haemophilus influenzae type b disease: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2014; 63:1.
2. Hiberix [Haemophilus b conjugate vaccine (tetanus toxoid conjugate)]. US Food and Drug Administration (FDA) approved product information. Revised April 2018. US Food & Drug Administration. Available online: www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm093833.htm (Accessed May 2, 2018).
3. Briere EC. Food and Drug Administration approval for use of Hiberix as a 3-dose primary Haemophilus influenzae type b (Hib) vaccination series. MMWR Morb Mortal Wkly Rep 2016; 65:418.
4. Vaxelis (diphtheria and tetanus toxoids and acellular pertussis adsorbed, inactivated poliovirus, Haemophilus b conjugate [meningococcal protein conjugate] and hepatitis B [recombinant] vaccine). United States Prescribing Information. Revised December, 2018. US Food & Drug Administration. Available online: www.fda.gov/BiologicsBloodVaccines/ucm629107.htm (Accessed on December 28, 2018).
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