Comparison of systemic glucocorticoid preparations

	Equivalent doses (mg)	Antiinflammatory activity relative to hydrocortisone*	Duration of action (hours)
Glucocorticoids
Short acting
Hydrocortisone (cortisol)	20	1	8 to 12
Cortisone acetate	25	0.8	8 to 12
Intermediate acting
Prednisone	5	4	12 to 36
Prednisolone	5	4	12 to 36
Methylprednisolone	4	5	12 to 36
Triamcinolone	4	5	12 to 36
Long acting
Dexamethasone	0.75	30	36 to 72
Betamethasone	0.6	30	36 to 72
Mineralocorticoids
Fludrocortisone	Not used for an antiinflammatory effect^¶. The typical dose of fludrocortisone for mineralocorticoid replacement is 0.1 to 0.2 mg.		12 to 36

The mineralocorticoid effect of commonly administered glucocorticoids may be estimated as follows:

When given at replacement doses, triamcinolone, dexamethasone, and betamethasone have no clinically important mineralocorticoid activity.
20 mg hydrocortisone and 25 mg of cortisone acetate each provide a mineralocorticoid effect that is approximately equivalent to 0.1 mg fludrocortisone.
Prednisone or prednisolone given at antiinflammatory doses ≥50 mg per day provide a mineralocorticoid effect that is approximately equivalent to 0.1 mg of fludrocortisone.

* Equivalent antiinflammatory dose shown is for oral or intravenous (IV) administration. Relative potency for intraarticular or intramuscular administration may vary considerably.
¶ The antiinflammatory potency is 10 to 15 times that of hydrocortisone; however, fludrocortisone is not used clinically as an antiinflammatory agent.

Data from:

Schimmer BP, Funder JW. ACTH, Adrenal Steroids, and Pharmacology of the Adrenal Cortex. In: Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 12th ed, Brunton LL, Chabner BA, Knollmann BC (Eds), McGraw-Hill Education 2011.
Liu D, Ahmet A, Ward L, et al. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. Allergy Asthma Clin Immunol 2013, 9:30.

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Comparison of systemic glucocorticoid preparations