Version May 2024
| Predominantly axonal pathophysiology |
| Initial tests: |
| Serum glucose and glycohemoglobin |
| Serum vitamin B12 level |
| SPEP and UPEP with immunofixation |
| Thyroid function tests |
| Serum antinuclear antibodies |
| Erythrocyte sedimentation rate |
| Additional testing, if history suggestive: |
| HIV serology |
| Urine/blood for heavy metals |
| Urine/blood for porphyrins |
| Rheumatoid factor |
| Sjögren syndrome testing (anti-Ro, anti-La antibodies) |
| Anti-Hu antibodies (in patients with sensory neuronopathy) |
| Lyme testing |
| Vitamin B1 (thiamine) erythrocyte transketolase activation assay or whole blood level |
| Methylmalonic acid and homocysteine levels (in patients with borderline low serum vitamin B12 levels) |
| Hepatitis screen (for types B and C) |
| Predominantly demyelinating pathophysiology |
| Initial tests: |
| SPEP and UPEP with immunofixation |
| Hepatitis screen (for types B and C) |
| Lumbar puncture |
| Additional testing, if history suggestive: |
| Antimyelin associated glycoprotein (MAG) antibodies (in patients with predominantly sensory symptoms) |
| Anti-GM1 antibodies (in patients with predominantly motor symptoms) |
| HIV |
| Genetic testing for Charcot-Marie-Tooth disease; generally, the electrophysiology is also suggestive of a hereditary condition |
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