Coagulation parameters in acute and chronic disseminated intravascular coagulation

Parameter	Acute (decompensated) DIC	Chronic (compensated) DIC
Platelet count	Reduced	Variable
Prothrombin time (PT)	Prolonged	Normal
Activated partial thromboplastin time (aPTT)	Prolonged	Normal
Thrombin time	Prolonged	Normal to slightly prolonged
Plasma fibrinogen	Reduced	Normal to elevated
Plasma factor V	Reduced	Normal
Plasma factor VIII	Reduced	Normal
Fibrin degradation products	Elevated	Elevated
D-dimer	Elevated	Elevated

In chronic DIC, the thrombin time is more sensitive than PT or aPTT to the effects of increased D-dimer and fibrin degradation products.

DIC: disseminated intravascular coagulation.

Graphic 63831 Version 2.0

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