Alendronate dose response in osteoporosis

Mean changes in BMD (measured by DXA) in the lumbar spine and femoral neck in postmenopausal women with osteoporosis treated with placebo or different doses of alendronate for three years. Alendronate caused an increase in bone density, an effect that was most pronounced at a dose of 10 mg/day (red squares). Bone density fell in the placebo group.