Reed-Sternberg cells in Hodgkin lymphoma

Left panel: Reed-Sternberg cell as seen in a bone marrow specimen. Right panel: Reed-Sternberg cells in a lymph node section. Note the characteristic clear area surrounding the nucleoli in the right panel (red arrows), giving an "owl's eyes" appearance to the nuclei. Shrinkage artifact causes these cells to separate from the adjacent tissue, leaving a clear area surrounding these cells (ie, lacunar cells, blue arrows).