Version May 2024
| Systolic BP ≥160 mmHg or diastolic BP ≥100 mmHg |
| Diabetes mellitus |
| Established CV disease including any history of: |
| Ischemic stroke, cerebral hemorrhage, or transient ischemic attack |
| Myocardial infarction, angina, coronary revascularization, or heart failure |
| Peripheral artery disease |
| Retinal hemorrhages or exudates and papilledema |
| Established or subclinical renal disease including: |
| Microalbuminuria or proteinuria (>30 mg/24 h) |
| Serum creatinine in men >1.5 mg/dL, women >1.4 mg/dL |
| Calculated or estimated glomerular filtration rate <60 mL/min/1.73 m2 |
| Subclinical organ damage previously documented by: |
| ECG or echocardiogram revealing left ventricular hypertrophy |
| Carotid ultrasound study revealing wall thickening or plaque |
| Three or more of the following CV risk factors: |
| Age (men >55 y, women >65 y) |
| Cigarette smoking |
| Dyslipidemia as measured by: |
| Total cholesterol >190 mg/dL or |
| Low-density lipoprotein cholesterol >130 mg/dL or |
| High-density lipoprotein cholesterol (men <40 mg/dL; women <46 mg/dL) or |
| Triglyceride >150 mg/dL |
| Fasting plasma glucose >100 mg/dL |
| Family history of premature CV disease (first-degree male relative age <55 y or first-degree female relative <65 y) |
| Abdominal obesity male waist circumference >40 in; female >35 in (in persons of East Asian ancestry: male waist circumference >35 in and for women >31 in) |
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